Researchers validate recurrence risk test for DCIS
Sunnybrook and ICES researchers and a team of investigators from across Ontario have validated a multi-gene biomarker panel shown to predict the risk of recurrence among patients diagnosed with ductal carcinoma in situ (DCIS) who had breast-conserving surgery treatment alone, as presented today at the 2014 San Antonio Breast Cancer Symposium.
DCIS means that cells that line the milk ducts in the breast have developed cancer features. DCIS is considered non-invasive which means it has not spread through the walls of the milk ducts to surrounding breast tissue, but some DCIS can go on to become invasive cancer. To date, there is no definitive way to know which cases will recur as DCIS or will go on to invasive disease.
Goals of treatment for newly diagnosed women are to reduce the risk of local recurrence and invasive breast cancer, while preserving as much of the breast as possible. Most women will be treated with breast conserving surgery (removes the DCIS part of the breast tissue), usually followed by radiation therapy.
“Currently clinical and pathological features do not reliably help identify individuals at low risk of recurrence after breast-conserving surgery. There is a great need to improve individualized treatment decisions to minimize both under and over treatment for these women,” says Dr. Eileen Rakovitch, lead investigator, radiation oncologist at Sunnybrook Health Sciences Centre and scientist at Sunnybrook Research Institute.