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Stem cell and skin regeneration

Human stem cells
Human stem cells printed using skin printer in order to engineer skin substitutes.

Human keratinocytes Human keratinocytes in a mono-layer culture.

We employ different in vitro and in vivo approaches to shed light on the process of healing after a burn injury. Using different sources of stem cells, we aim to create a skin substitute that can be used for burn patients. The focus of the group is finding new sources and combinations of stem cells to print the cells in a 3-D format.

Current projects are as follows:

Skin regeneration studies

  • regenerating skin and wound dressings for burn patients by using a microfluidic approach to print skin stem cells
  • generation of skin substitute by using pullulan and gelatin based material for skin regeneration
  • manufacturing a degradable electrospun pulycarbonate urethane-elatin (PUG) bilayer scaffolds for skin substitute

(Ab)normal wound healing studies

  • inflammasome component in keloids
  • role of serotonin during skin healing
  • lineage tracing of myeloid lineage cells post thermal injury
  • mechanism by which the Wnt/beta-catenin pathway in fibroblasts governs the fate of these cells during healing and regeneration

Muscle stem cells response post-thermal injury

  • role of satellite cells during muscle catabolism and muscle regeneration post thermal injury
  • the role of metformin in mitigating muscle phenotype post thermal injury

Liver progenitor cells post thermal injury

  • the response of liver progenitor cells post thermal injury
  • the role of myeloid lineage cells during liver fibrosis post thermal injury