Stem cell and skin regeneration
Human stem cells printed using skin printer in order to engineer skin substitutes.
Human keratinocytes in a mono-layer culture.
We employ different in vitro and in vivo approaches to shed light on the process of healing after a burn injury. Using different sources of stem cells, we aim to create a skin substitute that can be used for burn patients. The focus of the group is finding new sources and combinations of stem cells to print the cells in a 3-D format.
Current projects are as follows:
Skin regeneration studies
- regenerating skin and wound dressings for burn patients by using a microfluidic approach to print skin stem cells
- generation of skin substitute by using pullulan and gelatin based material for skin regeneration
- manufacturing a degradable electrospun pulycarbonate urethane-elatin (PUG) bilayer scaffolds for skin substitute
(Ab)normal wound healing studies
- inflammasome component in keloids
- role of serotonin during skin healing
- lineage tracing of myeloid lineage cells post thermal injury
- mechanism by which the Wnt/beta-catenin pathway in fibroblasts governs the fate of these cells during healing and regeneration
Muscle stem cells response post-thermal injury
- role of satellite cells during muscle catabolism and muscle regeneration post thermal injury
- the role of metformin in mitigating muscle phenotype post thermal injury
Liver progenitor cells post thermal injury
- the response of liver progenitor cells post thermal injury
- the role of myeloid lineage cells during liver fibrosis post thermal injury