Information for families
A study conducted by Roujeau and colleagues determined that severe blistering drug reactions may be connected to genetic factors (61). In this study, sulfonamide-related toxic epidermal necrolysis was associated with HLA-A29, B12 and DR7, while oxicam-related toxic epidermal necrolysis (TEN) was associated with HLA-A2 and B12 (61). In Han Chinese individuals, Stevens-Johnson Syndrome (SJS) induced by carbamazepine has been associated with the human leukocyte antigen HLA-B*1502 (62) and SJS induced by allopurinol with HLA-B*5801 (63).
All family members of patients with TEN/SJS should see their doctor to determine whether they may be at risk for developing TEN/SJS.