Scientist profiles A-F
CCaldwell, CurtisCallum, JeannieCarlyle, JamesCartotto, Robert
Dda Costa, LeodanteDabdoub, AlainDaneman, NickDavid, Elizabeth
Dr. James Carlyle
Carlyle is a senior scientist in Biological Sciences at SRI. He studies a type of white blood cell called natural killer (NK) cells, which target tumour cells and cells infected with bacteria and viruses for destruction. Central to his research is the question of how NK cells distinguish normal “self” cells from abnormal “nonself” cells like cancerous, infected or transplanted cells. This knowledge can be harnessed to design and improve immunotherapies for cancer and enhance the success of bone marrow transplants. Carlyle’s latest research describes the role of a cell surface protein in regulating innate immune responses and a new in vitro model to study how NK cells originate and function. He was recently awarded a grant from the Canadian Institutes of Health Research to support his work. A deeper understanding of NK cell biology has an impact on other fields including cancer immunology, infectious disease and transplantation biology.