Scientist profiles A-F
Sunnybrook Research Institute
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S1 12
Phone: 416-480-6100, ext. 3536
- B.Sc.,1988, biochemistry, Université de Montréal, Canada
- PhD, 1994, neuroscience, McGill University, Canada
- Postdoctoral fellowship, 1998, laboratory of genetics, Salk Institute for Biological Studies, San Diego, U.S.
Appointments and Affiliations:
- Senior scientist, Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute
- Associate professor, laboratory medicine and pathobiology, faculty of medicine, University of Toronto
- Alzheimer's disease
- Adult neurogenesis
- Stem cell therapy
- Gene therapy
- Delivery of therapeutics to the brain
- Neuronal degeneration and regeneration
- Brain development
Damage to the brain occurs following progressive neurodegenerative disorders (e.g., Alzheimer's disease), stroke, head trauma, cancer and invasive brain surgery. The capacity of the adult mammal brain to repair itself spontaneously is extremely limited; once damaged, most neuronal cells of the brain will degenerate and die.
The Brain Repair Group, led by Dr. Isabelle Aubert, focuses on developing therapies to stop neurodegeneration and promote regeneration under pathological conditions found in cases of Alzheimer's disease. Novel treatments are being tested in models of Alzheimer's disease to deliver therapeutic molecules across the blood-brain barrier, halt the toxicity of beta-amyloid peptides and induce neuronal survival and regeneration. Pharmacological approaches, immunotherapy and gene therapy are being evaluated in vitro and in vivo for their potential in maintaining neuronal health and inducing brain repair.
The Brain Repair Group aims to develop meaningful treatments that will lead to better brain and mind health, and ultimately restore and preserve critical cognitive functions such as learning and memory in cases of Alzheimer's disease.
Related News and Stories:
- Scientists capture tri-council funding: Operating grants support work in brain sciences and cancer research (July 15, 2014)
- Breaching barriers: A look at the promise of focused ultrasound to outsmart the brain's natural defenses and smuggle therapies into deep-brain territory to treat intractable disorders of the central nervous system (from 2013 SRI Magazine)
- Driving progress: National health research agency funds a dozen SRI scientists (April 25, 2014)
- In focus: Image-guided sound waves will change medicine; here's how (from SRI Magazine, 2010)
- Why nerve cells don't regenerate after brain injury and disease: study (April 5, 2010)
- SRI brain scientist speaks about her funded work with the Scottish Rite Charitable Foundation (268 KB, Winter 2010)
- Finding Solutions - Synthetic molecule may boost neuron function (January 2010)
- What Have You Learned From a Student? Researchers share their experience (2009, 116 KB)
- Wishes granted: CIHR recognizes nine scientists (6.6 MB, Spring 2009)
- Turning Japanese: An SRI trainee heads east (May 4, 2009)
- Trainees’ Post: Three undergrads dish on the summer student research program (6.1 MB, Autumn 2008)