Scientist profiles A-F
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room A3 42
Administrative assistant: Sue Santillo
- B.Sc., 1989, zoology, University of Maryland, U.S.
- PhD, 1999, biology, University of Maryland, U.S.
Appointments and Affiliations:
- Scientist, Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute
- Research director, Sonja Koerner Hearing Regeneration Laboratory, Sunnybrook Health Sciences Centre
- Associate professor, departments of otolaryngology – head & neck surgery; and laboratory medicine and pathobiology, University of Toronto
- Developmental neuroscience
- Wnt signalling transduction cascades
- Transcription factors
- Hearing research
Abnormalities in the developmental processes needed for the formation of the cochlea (hearing organ), result in deafness, one of the most common birth defects in humans. Furthermore, hearing impairment is the fastest growing, and one of the most prevalent chronic conditions facing older adults. Our research is focused on discovering and elucidating the molecular signaling cascades and transcription factors responsible for the generation and development of inner ear sensory hair cells (cells that detect sound), and auditory neurons (cells that transmit sound information from hair cells to the brain). Once lost, these cell types are never recovered in humans or mammals. The aim of our research is to understand how cochlear cells are generated during development to guide strategies for regeneration.
In addition to its important biological function, the auditory system is an exemplary structure to study developmental processes. As a model system, the complex development of the cochlea provides the opportunity to study organogenesis, pluripotency, plasticity, cell fate specification, differentiation and pattern formation, all of which are essential processes for the development of all organs and organisms.
- Nishimura K, Weichert RM, Liu W, Davis RL, Dabdoub A. Generation of induced neurons by direct reprogramming in the mammalian cochlea. Neuroscience. 2014 Sep;275:125–35.
- Jacques B, Montgomery WH, Uribe PM, Yatteau A, Asunicon JD, Resendiz G, Matsui JI, Dabdoub, A. The role of Wnt/β-catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line. Dev Neurobiol. 2014 Apr;74(4):438–56.
- Jacques B, Puligilla C, Weichert RM, Ferrer-Vaquer A, Hadjantonakis AK, Kelley MW and Dabdoub A. A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea. Development. 2012 Dec 1;139(23):4395–4404.
- Macheda ML, Sun WW, Kugathasan K, Hogan BM, Zhang YF, Jacques BE, Lieschke GJ, Dabdoub A and Stacker SA. The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. J Biol Chem. 2012 Aug 24;287(35):29312–23.
- Puligilla C, Dabdoub A, Brenowitz SD and Kelley MW. Sox2 induces neuronal formation in the developing mammalian cochlea. J Neurosci. 2010 Jan 13;30(2):714–22.
- Dabdoub A, Fritzsch B, Popper AN, Fay RR, editors. The primary auditory neurons of the mammalian cochlea. New York: Springer; 2016.
Related News and Stories:
- Better Medicine for Hearing Loss: Q&A with Alain Dabdoub (University of Toronto, Dec. 10, 2015)
- A motivation like no other: Researcher driven by his own experiences with hearing loss (June 26, 2015)
- Ears, unplugged: U of T researcher explores biological therapies for hearing loss (Jan. 9, 2014)
- The fundamentals: eyes and ears: Often overlooked as part of the brain, these portals of perception are essential to living to our full potential (from 2013 SRI Magazine)
- CV: Dr. Alain Dabdoub (July 2, 2013)
- U of T profile, department of otolaryngology, head & neck surgery
- U of T profile, department of laboratory medicine and pathobiology
The first three images depict the research of Dabdoub and colleagues, which was featured on the journal’s cover.