Scientist profiles G-L
Sunnybrook Research Institute
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room FG 08
Administrative Assistant: Abby Li
Phone: 416-480-6100, ext. 3185
- PhD, 1998, pharmacology, University of Toronto, Canada
Appointments and Affiliations:
- Senior scientist, Evaluative Clinical Sciences, Brain Sciences Research Program, Sunnybrook Research Institute
- Professor, departments of psychiatry, and pharmacology and toxicology, U of T
- Executive director, MORE research group
- Pharmacotherapy: neuropsychiatric symptoms secondary to central nervous system pathology
Neuropsychiatric symptoms associated with illness include mood changes, apathy, aggression and cognitive changes. These are common sequelae of many central nervous system disorders such as dementia, traumatic brain injury, cerebrovascular disease and stroke. Dr. Lanctôt's goal is to optimize the psychopharmacological management of these neuropsychiatric symptoms.
Her research addresses this goal by determining the underlying neurobiology of neuropsychiatric symptoms, examining predictors of treatment response, using novel pharmacological agents and carefully considering adverse drug events. Dr. Lanctôt's early focus was on the neurobiology of behavioural disorders associated with dementia. The goal of this research was to determine if behavioural subtypes can be linked to underlying neurochemical or neuropathologic dysfunction. A variety of tools including neuroimaging, pharmacogenetics and pharmacologic challenges are used in combination with pharmacotherapeutic trials.
This research will contribute to our understanding of the link between dysfunction in various neurotransmitters and neuropsychiatric symptoms. As such, it may allow Dr. Lanctôt's team to predict response to medications based on behavioural subtypes. At a broader level, it can provide the background for novel therapies.
A second focus of her research evaluates the impact of pharmacologic treatments at a population level, which includes measuring relevant health outcomes and quality of life, and modelling cost-benefit, cost-effectiveness and cost-utility of pharmacotherapies.
Related News and Stories:
- Treatment improves Alzheimer's symptoms (March 28, 2013)
- A shining moment: Trainee recognized with country's highest academic honour(June 7, 2012)
- Researchers studying emotional issues in Alzheimer's patients: Apathy and depression can be difficult to identify in Alzheimer's patients (Jan. 13, 2012)
- Boom, baby, boom!: Aging, dementia and the cost to family caregivers (from SRI magazine, 2011)
- Depression and heart disease: New link found (July 29, 2009)
- Spring up: Eleven SRI researchers are recognized by a quartet of funding bodies (June 3, 2008)
- Caring enough: Two SRI neuroscientists investigate the link between Alzheimer's disease and apathy (Feb. 19, 2008)
- The skeptics: Two SRI docs question new findings on a drug: A feature from SRI's Research Report 2004–2006
- A stroke of despair: A Sunnybrook scientist investigates the depths some older patients sink to after a stroke and their curious resistance to treatment (Nov. 8, 2006)