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SRI Profiles

Benjamin Goldstein, MD, PhD, FRCPC


Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room FG 53
Toronto ON
M4N 3M5

Phone: 416-480-6100, ext. 83720
Fax: 416-480-6878

Administrative Assistant: Vida Jennett
Phone: 416-480-5328
Fax: 416-480-6818


  • BA, 1996, psychology, University of Pennsylvania, U.S.
  • M.Ed., 1997, psychology, University of Toronto, Canada
  • PhD, 2001, psychology, U of T, Canada
  • MD, 2001, medicine, University of Calgary, Canada
  • FRCPC, 2006, psychiatry, U of T, Canada

Appointments and Affiliations:

  • Scientist, Evaluative Clinical Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute
  • Director of research, department of psychiatry, Sunnybrook Health Sciences Centre
  • Director, clinician scientist program, department of psychiatry, faculty of medicine, U of T
  • Associate professor, departments of psychiatry, pharmacology, and psychological clinical science, U of T
  • Adjunct assistant professor, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine

Research Foci:

  • Adolescent bipolar disorder
  • Vascular biology
  • Inflammation and oxidative stress
  • Comorbid cardiovascular disease and risk factors
  • Exercise
  • Neuroimaging
  • Novel therapeutics
  • Prevention

Research Summary:

Dr. Goldstein's research focuses on bipolar disorder among adolescents. Bipolar disorder is the fourth most disabling medical condition among adolescents worldwide. Adolescent-onset bipolar disorder can often be a particularly severe variant of this illness, underscoring the need for early identification and treatment. To date, assessment and treatment decisions have been guided primarily by subjective factors, and objective biological markers do not yet inform clinical decisions. Bipolar disorder is also associated with greatly increased risk of premature cardiovascular disease; thus far, this association is not well understood.

Dr. Goldstein's research encompasses three aims:

  • to identify biomarkers which enhance clinical decision-making for adolescents with bipolar disorder
  • to advance the understanding of shared biological factors underlying the links between bipolar disorder and cardiovascular disease
  • to examine the impact of novel pharmacological and behavioral treatments on psychiatric and cardiovascular outcomes among youth with bipolar disorder.

The lines of research informed by these three aims offer hope of reduced stigma, earlier identification and improved outcomes for adolescents with bipolar disorder. Dr. Goldstein and his colleagues are pursuing these lines of research with the support of the Brain and Behavior Research Foundation (NARSAD), the Canadian Institutes of Health Research, the Depressive and Bipolar Disorder Alternative Treatment Foundation, the Heart and Stroke Foundation of Ontario, the National Institute of Mental Health, the Ontario Mental Health Foundation and generous donations.

Selected Publications:

See current publications list at PubMed

  1. Goldstein BI, Carnethon MR, Matthews KA, McIntyre RS, Miller GE, Raghuveer G, Stoney CM, Wasiak H, McCrindle BW; American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young. Major depressive disorder and bipolar disorder predispose youth to accelerated atherosclerosis and early cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2015 Sep 8;132(10):965–86.
  2. Hatch J, Andreazza A, Olowoyeye O, Rezin GT, Moody A, Goldstein BI. Cardiovascular and psychiatric characteristics associated with oxidative stress markers among adolescents with bipolar disorder. J Psychosom Res. 2015 Sep;79(3):222–7.
  3. Goldstein BI, Schaffer A, Wang S, Blanco C. Excessive and premature new-onset cardiovascular disease among adults with bipolar disorder in the US NESARC cohort. J Clin Psychiatry. 2015 Feb;76(2):163–9.
  4. Goldstein BI, Kemp DE, Soczynska JK, McIntyre RS. Inflammation and the phenomenology, pathophysiology, comorbidity and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry. 2009 Aug; 70(8):1078–1090.
  5. Goldstein BI, Collinger KA, Lotrich F, Marsland AL, Gill MK, Axelson DA, Birmaher B. Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders. J Child Adolesc Psychopharmacol. 2011 Oct; 21(5):479–484.

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