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Scientist profiles G-L

SRI Profiles

Jean Gariépy, PhD

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room M7 434
Toronto, ON
M4N 3M5

Phone: 416-480-5710
Fax: 416-480-5714

Administrative Assistant: Kimberly Allen
Phone: 416-480-5718
Email: kimberly.allen@sunnybrook.ca

Education:

  • B.Sc., 1978, biochemistry specialization, Concordia University, Canada
  • PhD, 1983, biochemistry, University of Alberta, Canada 
  • Postdoctoral fellow, 1986, medical microbiology, Stanford University, U.S.

Appointments and Affiliations:

  • Senior scientist, Physical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute
  • SRI Research Chair in Biomolecular Engineering
  • Professor, department of medical biophysics, University of Toronto
  • Professor (cross-appointment), department of pharmaceutical sciences, University of Toronto

Research Foci:

  • Combinatorial libraries
  • Peptide-based delivery vectors
  • Tumour biology
  • Toxin transport

Research Summary:

The process of drug discovery needs to be accelerated if our society is to cope with rapidly rising numbers of cancer patients, newly unveiled mechanisms of drug resistance and the realization that cancer represents a collection of diseases that will require the tailoring of more selective therapies. Synthetic, combinatorial and genetic approaches are being applied in our laboratory to design peptide-oligonucleotide-based delivery shuttles or to re-engineer large structural templates such as bacterial toxins with the view to generating selective vehicles, imaging agents and therapies to treat cancer patients. The strategies developed in our laboratory will be applicable to other diseases.

Selected Publications:

See current publications list at PubMed.

  1. Ryan SO, Turner MS, Gariépy J, Finn OJ. Tumor antigen epitopes interpreted by the immune system as self or abnormal-self differentially affect cancer vaccine responses. Cancer Res. 2010 Jul 15; 70(14):5788-96.
  2. Beatty PL, Narayanan S, Gariépy J, Ranganathan S, Finn OJ. Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer. Cancer Prev Res (Phila). 2010 Apr; 3(4):438­-46.
  3. Orava EW, Cicmil N, Gariépy J. Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals. Biochim Biophys Acta. 2010 Dec; 1798(12):2190-200.
  4. Cheung MC, Revers L, Perampalam S, Wei X, Kiarash R, Green DE, Abdul-Wahid A, Gariepy J. An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo. Mol Cancer. 2010 Feb 3; 9:28.
  5. Hassane FS, Ivanova GD, Bolewska-Pedyczak E, Abes R, Arzumanov AA, Gait MJ, Lebleu B, Gariépy J. A Peptide-based dendrimer that enhances the splice-redirecting activity of PNA conjugates in cells. Bioconjug Chem. 2009 Aug 19; 20(8):1523-1530.
  6. Ferreira CS, Cheung MC, Bisland S, Missailidis S, Gariepy J. Phototoxic aptamers selectively enter and kill epithelial cancer cells. Nucleic Acids Res. 2009 Feb; 37(3):866-76.

 

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