|Scientist profiles G-L|
Sunnybrook Research Institute
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room D7 04
Department of Surgery, Division of Plastic Surgery
University of Toronto
- MD, 1994 Eberhard-Karls University, Germany
- MMS, 1999 Graduate School of Biomedical Science, University of Texas Medical Branch (UTMB), USA
- PhD, 2002, Experimental Surgery (Molecular Biology) University of Regensburg, Germany
Appointments and Affiliations:
- Senior scientist, biological sciences, Trauma, Emergency & Critical Care Research Program, Sunnybrook Research Institute
- Director, Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre
- Associate professor, department of surgery division of plastic & reconstructive surgery, University of Toronto
- Associate professor, department of immunology, U of T
- Stress response
- Hypermetabolism, including insulin resistance
- Cell regeneration
- Gene transfer
- Stem cells
In May 2010, Dr. Jeschke was appointed director of the Ross Tilley Burn Centre at Sunnybrook Health Sciences Centre. He was also appointed surgeon-scientist in the division of plastic & reconstructive surgery, department of surgery and department of immunology, the University of Toronto. Dr. Jeschke is also an associate professor of surgery at U of T.
Dr. Jeschke has been caring for burn patients and conducting research in the field of burns for nearly 20 years, and in that time has published more than 220 peer-reviewed articles and has authored several books and chapters on burn care. The quality of his research is reflected by his funding. He has been funded continuously since 2000 by the German Research Council, National Institutes of Health, Shriners Hospital for Children and foundations. He was recently awarded grants from the Canada Foundation for Innovation and the Canadian Institutes of Health Research.
In addition to his many accomplishments as a researcher, Dr. Jeschke is a highly respected educator. He has mentored and trained more than 45 PhD, MD and other graduate students in the field of burn care and burn-related research. He is a sought-after speaker and has lectured around the world. Dr. Jeschke is a member of various organizations including the American Burn Association, Association for Academic Surgery, European Shock Society, Shock Society, International Society of Burn Injuries, Surgical Infection Society, Society for Critical Care Medicine, American Association for the Surgery of Trauma and Society University Surgeons. He serves on several boards and committees. He also is a reviewer for the National Institutes of Health and U.S. Department of Defense.
Dr. Jeschke has won numerous awards for teaching and research, including the prestigious Fellow Award of the American Surgical Association Foundation; first prize poster presentation, American Burn Association; Surgery Specialty Award; Society of Critical Care Medicine; Von-Langenbeck-Prize from the German College of Surgeons; Prize for the best scientific work from the German College of Surgeons, Critical Care Chapter; Dr. Werner Fekl Förderprize of the German Society of Critical Care Medicine; best scientific presentation at the first world meeting of the Surgical Infection Society; wound healing prize, German College of Surgeons; Otto-Götze Prize of the Bavarian Society of Surgery; Johann-Nepomuk-von-Nussbaum Prize der Bayerischen Gesellschaft für Chirurgie; and American College of Surgeons Committee on Trauma, Region VI. Winner Residents Award and selected for presentation at the National Competition, Washington DC (1998).
Burn is a severe trauma to patients inducing various
responses in the body such as stress, inflammation, hypermetabolism, catabolism
and alterations in the entire glucose, fat and amino acid equilibrium. Cells
are undergoing major stress and die, thus comprising organ function. The source
of the stress is most likely the burned area inducing these detrimental changes
via several signals and mediators. The goal of our research is to attenuate
stress hypermetabolic and catabolic responses, and improve cell regeneration
and survival. We are studying the stress-induced changes in the liver and
various other tissues at a cellular and cell organelle level in an attempt to
identify key signalling molecules and pathways that may be altered to improve
cell survival and organ function.
We also study various potential perturbations to improve the cellular stress response which can be rapidly implemented in the clinical arena. We also study new techniques to cover the wounds of a severely burned patient, not only with the patient's own skin, but also using adult stem cells.
Overall, the research focus of our laboratory is to improve morbidity and mortality of severely injured trauma patients, such as burn patients, and to identify major modulating aspects of these responses.
See current publications list at PubMed.
- Jeschke MG, Finnerty CC, Herndon DN, Song J, Boehning D, Tompkins RG, Baker HV, Gauglitz GG. Severe Injury Is Associated With Insulin Resistance, Endoplasmic Reticulum Stress Response, and Unfolded Protein Response. Ann Surg. 2012 Feb; 255(2):370–378.
- Kraft R, Herndon DN, Al-Mousawi AM, Williams FN, Kulp G, Mecott-Rivera G, Lee JO, Jeschke MG. Burn Size and Survival Probability in Paediatric Patients in Modern Burn Care: A Prospective Observational Cohort Study. Lancet. 2012 Mar; 379(9820):1013–1021.
- Jeschke MG, Gauglitz GG, Kulp G, Williams FN, Kraft R, Herndon DN. Long-term persistence of the pathophysiologic response to severe burn injury. PLoS One. 2011; 6(7): e21245.
- Jeschke MG, Kraft R, Song J, Gauglitz GG, Cox RA, Brooks NC, Finnerty CC, Kulp GA, Herndon DN, Boehning D. Insulin Protects against Hepatic Damage Post-Burn. Mol Med. 2011 May¬-Jun; 17(5-6):516–522.
- Jeschke MG, Kulp G, Kraft R, Finnerty CC, Lee JO, Herndon DN. Intensive insulin control in severely burned pediatric patients: a prospective randomized trial. Am J Respir Crit Care Med. 2010 Aug; 182(3):351–359.
- Gauglitz GG, Toliver-Kinsky TE, Williams FN, Kulp GA, Song J, Herndon DN, Jeschke MG. Insulin Increases Resistance to Burn Wound Infection-Associated Sepsis. Crit Care Med. 2010 Jan; 38(1): 202–208.
Related News and Stories:
- A spoonful of sugar (from Sunnybrook Research Institute magazine, 2011)
- CV: Dr. Marc Jeschke (Nexus, Summer 2010)