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SRI Profiles

Marc Jeschke, MD, PhD, FACS, FRCSC

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room D7 04
Toronto, Ontario
M4N 3M5

Phone: 416-480-6703
Fax: 416-480-6763

Administrative Assistant: Susan Kurtz
Email: susan.kurtz@sunnybrook.ca

Education:

  • MD, 1994, Eberhard-Karls University, Germany
  • Master of medical science, 1999, graduate school of biomedical science, University of Texas Medical Branch, U.S.
  • PhD, 2002, experimental surgery (molecular biology) University of Regensburg, Germany

Appointments and Affiliations:

Research Foci:

  • Burn
  • Trauma
  • Stress response
  • Inflammation
  • Hypermetabolism, including insulin resistance
  • Cell regeneration
  • Gene transfer
  • Stem cells

Bio:

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In May 2010, Dr. Jeschke was appointed director of the Ross Tilley Burn Centre at Sunnybrook Health Sciences Centre. He was also appointed surgeon-scientist in the division of plastic and reconstructive surgery, department of surgery and department of immunology at the University of Toronto. Dr. Jeschke is also an associate professor of surgery at U of T.

Dr. Jeschke has been caring for burn patients and conducting research in the field of burns for nearly 20 years, and in that time has published more than 320 peer-reviewed articles and has authored several books and chapters on burn care. The quality of his research is reflected by his funding. He has been funded continuously since 2000 by the German Research Council, National Institutes of Health, Shriners Hospital for Children and foundations. He was recently awarded grants from the Canada Foundation for Innovation and the Canadian Institutes of Health Research (CIHR).

In addition to his many accomplishments as a researcher, Dr. Jeschke is a highly respected educator. He has mentored and trained more than 75 PhD, MD and other graduate students in the field of burn care and burn-related research. He is a sought-after speaker and has lectured around the world. Dr. Jeschke is a member of various organizations including the American Burn Association, Association for Academic Surgery, European Shock Society, Shock Society, International Society of Burn Injuries, Surgical Infection Society, Society for Critical Care Medicine, American Association for the Surgery of Trauma and Society University Surgeons. He serves on several boards and committees. He also is a reviewer for the National Institutes of Health, U.S. Department of Defense and CIHR.

Dr. Jeschke has won numerous awards for teaching and research, including the prestigious Fellow Award of the American Surgical Association Foundation; first prize poster presentation, American Burn Association; Surgery Specialty Award; Society of Critical Care Medicine; Von-Langenbeck-Prize from the German College of Surgeons; Prize for the best scientific work from the German College of Surgeons, Critical Care Chapter; Dr. Werner Fekl Förderprize of the German Society of Critical Care Medicine; best scientific presentation at the first world meeting of the Surgical Infection Society; wound healing prize, German College of Surgeons; Otto-Götze Prize of the Bavarian Society of Surgery; Johann-Nepomuk-von-Nussbaum Prize der Bayerischen Gesellschaft für Chirurgie; and American College of Surgeons Committee on Trauma, Region VI. Winner of the Residents Award and selected for presentation at the National Competition in Washington DC (1998).

Research Summary:

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Burn is a severe trauma to patients inducing various responses in the body such as stress, inflammation, hypermetabolism, catabolism and alterations in the entire glucose, fat and amino acid equilibrium. Cells are undergoing major stress and die, thus compromising organ function. The source of the stress is most likely the burned area inducing these detrimental changes via several signals and mediators. The goal of our research is to attenuate stress hypermetabolic and catabolic responses, and improve cell regeneration and survival. We are studying the stress-induced changes in the liver and various other tissues at a cellular and cell organelle level in an attempt to identify key signalling molecules and pathways that may be altered to improve cell survival and organ function.

We also study various potential perturbations to improve the cellular stress response which can be rapidly implemented in the clinical arena. We also study new techniques to cover the wounds of a severely burned patient, not only with the patient's own skin, but also using adult stem cells.

Overall, the research focus of our laboratory is to improve morbidity and mortality of severely injured trauma patients, such as burn patients, and to identify major modulating aspects of these responses.

Selected Publications:

See current publications list at PubMed.

  1. Jeschke MG, Abdullahi A, Burnett M, Rehou S, Stanojcic M. Glucose control in severely burned patients using metformin: an interim safety and efficacy analysis of a Phase II randomized controlled trial. Ann Surg. 2016 Sep;264(3):518–27.
  2. Xiu F, Stanojcic M, Wang V, Qi P, Jeschke MG. C-C chemokine receptor type 2 expression on monocytes before sepsis onset is higher than that of postsepsis in septic burned patients: a new predictor for sepsis in burned injury. Ann Surg. 2016 Aug;264(2):392–8.
  3. Stanojcic M, Chen P, Xiu F, Jeschke MG. Impaired immune response in elderly burn patients: new insights into the immune-senescence phenotype. Ann Surg. 2016 Jul;264(1):195–202.
  4. Jeschke MG, Patsouris D, Stanojcic M, Abdullahi A, Rehou S, Pinto R, Chen P, Burnett M, Amini-Nik S. Pathophysiologic response to burns in the elderly. EBioMedicine. 2015 Jul 31;2(10):1536–48.
  5. Patsouris D, Qi P, Abdullahi A, Stanojcic M, Chen P, Parousis A, Amini-Nik S, Jeschke MG. Burn induces browning of the subcutaneous white adipose tissue in mice and humans. Cell Rep. 2015 Nov 24;13(8):1538–44.

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