|Scientist profiles G-L|
Sunnybrook Research Institute
CreATe IVF Fertility Clinic
790 Bay Street, Suite 1100
Administrative Assistant: Stephanie Grover
- M.D., 1983, University of Toronto, Canada
- FRSC(C), 1988, Dept of Obstetrics and Gynecology, University of Toronto, Canada.
- FACOG(REI), 1991, Dept of Reproductive Sciences, University of California, San Francisco, USA.
Appointments and Affiliations:
- Associate scientist, biological sciences - Women and Babies Research Program, Sunnybrook Research Institute
- Director, Division of Reproductive Biology, Department of Obstetrics and Gynecology, Sunnybrook Heath Sciences Centre.
- Director of CReATe Fertility Centre.
- Director of CReATe Cord Blood Bank
- Chair, OMA Section of Reproductive Biology.
- Associate Professor, Obstetrics and gynecology, faculty of medicine, University of Toronto
- Reproductive Biology
- Stem Cell Biology
- Reproductive Endrocrinology
- Reproductive Immunology
The foci of Dr. Librach's clinical and basic services research are as follows:
- Clinical Studies on methods to improve treatment of infertility (PCOS, Rec Pregnancy Losses, Assisted Reproduction and Endometriosis)
- Development of testing to predict Pre-eclampsia.
- Study of the role of HLA-G as an immuno-protective molecule in reproduction, transplantation and cancer.
- The molecular basis of Polycystic Ovary Syndrome
- Basic research on male reproductive failure
- Preimplantation Genetic analysis in human embryo development.
- Stem Cells from Umbilical Cord Tissue for the treatement of Spinal Cord injury, Diabetes Mellitus and study of aberrant Gamete development.
See current publications list at PubMed.
- Shang-mian Yie, Liang-hong Li, Rong Xiao, and Clifford L. Librach. A single base-pair mutation in the 3’-untranslated region of human leukocyte antigen G mRNA is associated with preeclampsia. Molecular Human Reproduction 2008 14(11):649-653
- S Yie, L Li, G Li, R Xiao, and C L Librach. Progesterone Enhances Human Leukocyte Antigen G (HLA-G) Gene Expression In JEG-3 Choriocarcinoma Cell and Human Cytotrophoblasts In Vitro Human Reproduction (21:46-51, 2006)
- SM Yie, RT Taylor, and CL. Librach. Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia (PE) later in pregnancy. Am J Obstet Gynecol, 193:204-8, 2005
- Shang-mian Yie, Hanna Balakier, Gelareh Motamedi, and Clifford L Librach. Secretion of human leukocyte antigen-G (HLA-G) by human embryos is associated with a higher IVF pregnancy rate Fertility and Sterility - 83(1) p30-6, 2005
Related News and Stories:
- Knowledge of infertility low in urban teens (Sept 28, 2008)