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Sunnybrook Research Institute

Clifford Librach
Clifford Librach

Senior Scientist

CreATe IVF Fertility Clinic
790 Bay Street, Suite 1100
Toronto, Ontario
M5G 1N8

Phone: 416-323-7727, ext. 21
Fax: 416.323.7334

Administrative Assistant: Stephanie Grover
Phone: 416.413.0111
Email: stephanieg@createivf.com


Education:

  • M.D., 1983, University of Toronto, Canada
  • FRSC(C), 1988, Dept of Obstetrics and Gynecology, University of Toronto, Canada.
  • FACOG(REI), 1991, Dept of Reproductive Sciences, University of California, San Francisco, USA.

Appointments and Affiliations:

  • Associate scientist, biological sciences - Women and Babies Research Program, Sunnybrook Research Institute
  • Director, Division of Reproductive Biology, Department of Obstetrics and Gynecology, Sunnybrook Heath Sciences Centre.
  • Director of CReATe Fertility Centre.
  • Director of CReATe Cord Blood Bank
  • Chair, OMA Section of Reproductive Biology.
  • Associate Professor, Obstetrics and gynecology, faculty of medicine, University of Toronto

Research Foci:

  • Infertility
  • Reproductive Biology
  • Stem Cell Biology
  • Reproductive Endrocrinology
  • Reproductive Immunology

Research Summary:

The foci of Dr. Librach's clinical and basic services research are as follows:

  1. Clinical Studies on methods to improve treatment of infertility (PCOS, Rec Pregnancy Losses, Assisted Reproduction and Endometriosis)
  2. Development of testing to predict Pre-eclampsia.
  3. Study of the role of HLA-G as an immuno-protective molecule in reproduction, transplantation and cancer.
  4. The molecular basis of Polycystic Ovary Syndrome
  5. Basic research on male reproductive failure
  6. Preimplantation Genetic analysis in human embryo development.
  7. Stem Cells from Umbilical Cord Tissue for the treatement of Spinal Cord injury, Diabetes Mellitus and study of aberrant Gamete development.

Selected Publications:

See current publications list at PubMed.

  1. Shang-mian Yie, Liang-hong Li, Rong Xiao, and Clifford L. Librach. A single base-pair mutation in the 3’-untranslated region of human leukocyte antigen G mRNA is associated with preeclampsia.    Molecular Human Reproduction 2008 14(11):649-653
  2. S Yie, L Li, G Li, R Xiao, and C L Librach. Progesterone Enhances Human Leukocyte Antigen G (HLA-G) Gene Expression In JEG-3 Choriocarcinoma Cell and Human Cytotrophoblasts In Vitro Human Reproduction (21:46-51, 2006)
  3. SM Yie, RT Taylor, and CL. Librach. Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia (PE) later in pregnancy.  Am J  Obstet Gynecol, 193:204-8, 2005
  4. Shang-mian Yie, Hanna Balakier, Gelareh  Motamedi, and Clifford L  Librach. Secretion of human leukocyte antigen-G (HLA-G) by human embryos is associated with a higher IVF pregnancy rate  Fertility and Sterility - 83(1) p30-6, 2005

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