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Scientist profiles G-L

David Gladstone, B.Sc., MD, PhD, FRCPC


Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room A4 42
Toronto, ON
M4N 3M5

Phone: 416-480-4866
Fax: 416-480-5753

Administrative Assistant: Melissa Cherny-Bayer
Phone: 416-480-4866


  • B.Sc., 1992, human biology, University of Toronto, Canada
  • MD, 1996, U of T, Canada
  • Certificate in medical education, Institute of Medical Sciences, U of T, Canada
  • FRCPC, 2003
  • PhD, 2006, U of T, Canada

Appointments and Affiliations:

  • Scientist, Evaluative Clinical Sciences, Brain Sciences Research Program, Sunnybrook Research Institute
  • Assistant professor, department of medicine (neurology), U of T
  • Co-leader, University of Toronto Stroke Program (UTSP)
  • Director, Regional Stroke Prevention Clinic and Acute TIA Unit, Sunnybrook Health Sciences Centre
  • Co-director, Inpatient Stroke Neurology Services and Stroke Research Unit, Sunnybrook
  • Director, Sunnybrook Stroke Fellowship
  • Adjunct scientist, Institute for Clinical Evaluative Sciences (ICES)
  • Scientist, Canadian Partnership for Stroke Recovery

Research Foci:

  • Stroke prevention
  • Atrial fibrillation
  • Carotid artery disease
  • Transient ischemic attacks
  • Intracerebral hemorrhage
  • Emergency stroke treatment
  • Clinical trials and outcomes research
  • Quality of care and patient safety
  • Post-stroke recovery and neurorehabilitation

Research Summary:

Dr. Gladstone completed his PhD in clinical stroke recovery research through the Royal College Clinician-Scientist Training Program and Institute of Medical Sciences at University of Toronto with a CIHR-Heart and Stroke Foundation Fellowship Award. His thesis project earned the McNaughton national neurology research award from the Canadian Neurological Society. He received the Sunnybrook Department of Medicine Young Investigator Award, Ontario Ministry of Research and Innovation Early Researcher Award, and Clinician-Scientist Award from the Heart and Stroke Foundation of Ontario.

Dr. Gladstone is interested in practical, clinically-relevant research that can enhance patient care. He is principal investigator of national multicentre clinical trials funded by peer-reviewed grants from the Canadian Stroke Network and the Canadian Institutes of Health Research (CIHR), and a local multicentre registry study funded by the Ontario Stroke Network. He leads the EMBRACE study, a randomized trial that aims to improve the early detection of atrial fibrillation in patients with stroke and TIA, and the SPOTLIGHT study, a randomized trial to study an innovative image-guided emergency treatment protocol for patients with hemorrhagic stroke. Dr. Gladstone has also directed projects within the Registry of the Canadian Stroke Network to evaluate quality of care, safety issues and practice gaps in stroke management, including publications highlighting the underuse of warfarin in high-risk patients with atrial fibrillation and long wait times for carotid artery surgery for stroke prevention. He has authored or co-authored 99 scientific publications spanning the spectrum of stroke care, including stroke prevention, prehospital care, emergency treatment of ischemic and hemorrhagic stroke, stroke/TIA epidemiology, clinical trial design, outcome measures in stroke recovery and neurorehabilitation.

Dr. Gladstone is actively engaged in medical education and has provided neurological training for over 100 medical undergraduate and postgraduate trainees at University of Toronto. He received the Marotta Award for neurology education in the University of Toronto Neurology Training Program. He is a research supervisor and mentor for fellows, residents, students and junior faculty. He has been an invited guest speaker at local, regional, national and international meetings promoting best practices in stroke diagnosis, treatment and prevention, and has delivered more than 300 lectures to family physicians, internists, geriatricians, neurologists, cardiologists, ER physicians, physiatrists, dentists, nurses, physiotherapists, paramedics, pharmacists, researchers and the public. Dr. Gladstone has been working to develop Sunnybrook as a premier regional stroke centre and has been site principal investigator for several national and international clinical trials of new treatments for acute ischemic and hemorrhagic stroke.

Selected Publications:

See current publications list at PubMed.

  1. Gladstone DJ, Rodan LH, Sahlas DJ, Lee L, Murray BJ, Ween JE et al. A citywide prehospital protocol increases access to stroke thrombolysis in Toronto. Stroke. 2009 Dec;40(12):3841–4.
  2. Gladstone DJ, Oh J, Fang J, Lindsay MP, Tu JV, Silver FL et al. Urgency of carotid endarterectomy for secondary stroke prevention: Results from the Registry of the Canadian Stroke Network. Stroke. 2009 Aug;40(8):2776–82.
  3. Thompson A, Kosior J, Gladstone DJ, Hopyan JJ, Symons S, Romero F et al, for the PREDICT/Sunnybrook ICH CTA Study Group. Defining the CT angiography 'spot sign' in primary intracerebral hemorrhage. Can J Neurol Sci. 2009 Jul;36(4):456–61.
  4. Gladstone DJ, Bui E, Fang J, Laupacis A, Lindsay MP, Tu JV et al. Potentially preventable strokes in high risk patients with atrial fibrillation who are not adequately anticoagulated. Stroke 2009;40(1):235-40.
  5. Gladstone DJ, Danells CJ, Armesto A, Staines WR, McIlroy WE, Graham SJ, Herrmann N, Szalai JP, Black SE, for the Subacute Therapy with Amphetamine and Rehabilitation for Stroke (STARS) Study Group. Physiotherapy coupled with dextroamphetamine for motor rehabilitation after hemiparetic stroke: A randomized controlled trial. Stroke 2006;37(1):179–185.

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