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SRI Profiles

Michael Julius, PhD

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room A3 33
Toronto, ON
M4N 3M5

Phone: 416-480-6100, ext. 7204
Fax: 416-480-4351

Administrative Assistant: Jeanette Andreatta
Phone: 416-480-6100, ext. 7204


  • B.Sc., 1970, McGill University, Canada
  • PhD, 1974, Stanford University, U.S.

Appointments and Affiliations:

  • Vice-president, research, Sunnybrook Health Sciences Centre
  • Vice-president, research, Sunnybrook Research Institute
  • Senior scientist, Biological SciencesOdette Cancer Research Program, Sunnybrook Research Institute
  • Professor, department of immunology, University of Toronto
  • Professor, department of medical biophysics, U of T

Research Foci:

  • Immunology
  • Diseases of the immune system
  • Signal transduction in T cell homeostasis
  • Role of src family kinases in immune dysfunction

Research Summary:

Our body's immune system is a complex collection of cells and soluble substances produced by cells. These components interact with one another and play a fundamental role in maintaining good health. In a healthy individual, the interactions and communications among all immune system components result in protective responses to disease caused by infection from viruses and bacteria. In the absence of infection, having a strong immune system promotes rapid wound healing.

Sometimes, for reasons we do not yet understand, the immune system becomes unable to discriminate between harmful infection and normal healthy organs of the body. This can cause debilitating diseases that affect joints, leading to arthritis; affect the insulin-producing cells of the pancreas, leading to diabetes; affect the gut, leading to inflammatory bowel diseases; and can also cause allergic reactions.

Dr. Julius aims to understand the nature of each immune system component and characterize, at a cellular and molecular level, how the interactions among them lead to normal healthy immune responses and good health.

Once we figure out how the immune system functions in healthy individuals, we will be able to design ways to increase its ability to protect our bodies, and we will be able to pinpoint and "fix" the components contributing to circumstances that result in the improper functioning of the immune system.

Selected Publications:

See current publications list at PubMed.

  1. Moemeni B, Vacaresse N, Vainder M, Wortzman M, Watts T, Veillette A, Gajewski TF, Julius M. Fyn expression predicates both protective immunity and onset of autoimmunity. Open J. Immunol. 2015 Dec 5;(5):244–59.
  2. Filipp D, Moemeni B, Ferzoco A, Kathirkamathamby K, Zhang J, Davidson D, Veillette A, Julius M. Lck-dependent Fyn activation requires c-terminus dependent targeting of kinase active Lck to lipid rafts. J. Biol. Chem. 2008 Sep;283(39):26409–22.
  3. Filipp D, Julius M. Lipid rafts: resolution of the “fyn problem”? Mol Immunol. 2004 Jul; 41(6–7):645–56.
  4. Fillip D, Zhang J, Leung BL, Shaw A, Levin SD, Veillette A, Julius M. Regulation of Fyn through translocation of activated Lck into lipid rafts J. Exp Med. 2003 May;197(9):1221–7.
  5. Watanabe R, Murakami Y, Marmor MD, Inoue N, Maeda Y, Hino J, Kangawa K, Julius M, Kinoshita T. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J. 2000 Aug;19(16):4402–11.
  6. Haughn L Gratton S, Caron L, Sékaly R, Veillette A, Julius MH. Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth signals through the αβ T Cell receptor. Nature. 1992;358(6384):328–31.
  7. Newell MK, Haughn L, Maroun C, Julius MH. Death of mature T Cells by separate ligation of CD4 and the T cell receptor for antigen. Nature. 1990 Sep;347(6290):286–9.

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