Scientist profiles G-L
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room A3 33
Administrative Assistant: Jeanette Andreatta
Phone: 416-480-6100, ext. 7204
- B.Sc., 1970, McGill University, Canada
- PhD, 1974, Stanford University, U.S.
Appointments and Affiliations:
- Vice-president, research, Sunnybrook Health Sciences Centre
- Vice-president, research, Sunnybrook Research Institute
- Senior scientist, Biological Sciences, Odette Cancer Research Program, Sunnybrook Research Institute
- Professor, department of immunology, University of Toronto
- Professor, department of medical biophysics, U of T
- Diseases of the immune system
- Signal transduction in T cell homeostasis
- Role of src family kinases in immune dysfunction
Our body's immune system is a complex collection of cells and soluble substances produced by cells. These components interact with one another and play a fundamental role in maintaining good health. In a healthy individual, the interactions and communications among all immune system components result in protective responses to disease caused by infection from viruses and bacteria. In the absence of infection, having a strong immune system promotes rapid wound healing.
Sometimes, for reasons we do not yet understand, the immune system becomes unable to discriminate between harmful infection and normal healthy organs of the body. This can cause debilitating diseases that affect joints, leading to arthritis; affect the insulin-producing cells of the pancreas, leading to diabetes; affect the gut, leading to inflammatory bowel diseases; and can also cause allergic reactions.
Dr. Julius aims to understand the nature of each immune system component and characterize, at a cellular and molecular level, how the interactions among them lead to normal healthy immune responses and good health.
Once we figure out how the immune system functions in healthy individuals, we will be able to design ways to increase its ability to protect our bodies, and we will be able to pinpoint and "fix" the components contributing to circumstances that result in the improper functioning of the immune system.
- Moemeni B, Vacaresse N, Vainder M, Wortzman M, Watts T, Veillette A, Gajewski TF, Julius M. Fyn expression predicates both protective immunity and onset of autoimmunity. Open J. Immunol. 2015 Dec 5;(5):244–59.
- Filipp D, Moemeni B, Ferzoco A, Kathirkamathamby K, Zhang J, Davidson D, Veillette A, Julius M. Lck-dependent Fyn activation requires c-terminus dependent targeting of kinase active Lck to lipid rafts. J. Biol. Chem. 2008 Sep;283(39):26409–22.
- Filipp D, Julius M. Lipid rafts: resolution of the “fyn problem”? Mol Immunol. 2004 Jul; 41(6–7):645–56.
- Fillip D, Zhang J, Leung BL, Shaw A, Levin SD, Veillette A, Julius M. Regulation of Fyn through translocation of activated Lck into lipid rafts J. Exp Med. 2003 May;197(9):1221–7.
- Watanabe R, Murakami Y, Marmor MD, Inoue N, Maeda Y, Hino J, Kangawa K, Julius M, Kinoshita T. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J. 2000 Aug;19(16):4402–11.
- Haughn L Gratton S, Caron L, Sékaly R, Veillette A, Julius MH. Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth signals through the αβ T Cell receptor. Nature. 1992;358(6384):328–31.
- Newell MK, Haughn L, Maroun C, Julius MH. Death of mature T Cells by separate ligation of CD4 and the T cell receptor for antigen. Nature. 1990 Sep;347(6290):286–9.
Related News and Stories:
- Sunnybrook Research Institute presents biomedical engineering student with prestigious prize: Undergraduates compete for a chance to win cash award (Jan. 11, 2016)
- A celebration of cardiac research: Researchers showcase heart program’s cutting-edge work (Nov. 25, 2015)
- National agency recognizes scientific excellence at Sunnybrook Research Institute: Scientists score high with multimillion-dollar funding investment (Oct. 13, 2015)
- Poster competition turns on the heat: Summer students showcase diverse research projects (Aug. 26, 2015)
- A hearty showcase of cardiac care: Researchers present state-of-the-art cardiovascular interventions at annual research day (Nov. 26, 2014)
- Driving progress: National health research agency funds a dozen SRI scientists (April 25, 2014)
- Competition spurs high scores: Scientists secure funding with federal agency (July 25, 2013)
- Continuing education: School's out, but learning doesn't stop for summer students at SRI (May 29, 2013)
- FedDev Ontario invests in large-scale collaboration in research innovation: video success stories feature Sunnybrook Research Institute (June 13, 2013)
- Cyclotron installation marks milestone: new facility to improve access to medical imaging (June 10, 2013)
- Eyes on the prize: National student competition recognizes excellence in biomedical research (Jan. 4, 2013)
- Spring's fortunes: Scientists win operating grants in federal agency's latest funding round (July 9, 2012)
- Scientists score high with operating funds: CIHR invests in eight researchers in its latest competition (May 30, 2012)
- A hearty success: annual research day showcases the latest in cardiac care (December 16, 2011)
- A glimpse of tomorrow's medicine: research day celebrates the promise of image-guided therapies (November 25, 2011)
- Doors open to new biomedical imaging research suite: Leading-edge facility will advance work in image-guided therapeutics and technology development (November 25, 2011)
- Sunnybrook Research Institute celebrates milestone in imaging research: State-of-the-art laboratory will advance innovative work in histopathology (October 25, 2011)
- Brain scientists give premier a glimpse into the future: Dalton McGuinty learns about magnetic resonance-guided focused ultrasound (November 15, 2010)
- Man of distinction: Dr. Michael Julius awarded Man of Distinction 2010 award by Israel Cancer Research Fund (October 20, 2010)
- Main stage: First scientific day on the promise and future of image-guided therapeutics commands a packed house (July 19, 2010)
- Seven score operating grants (May 14, 2010)
- A centre is born: Canada Foundation for Innovation invests $74.6 million in Centre for Research in Image-Guided Therapeutics (August 20, 2008)
- Spring up: Eleven SRI researchers are recognized by a quartet of funding bodies (June 3, 2008)
- $23 million awarded for health research (February 7, 2008)