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SRI Profiles

George Mochizuki photo
George Mochizuki, BPHE, M.Sc., PhD

Scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room M6 178
Toronto, ON
M4N 3M5

Phone: 416-480-6100, ext. 83737
Fax: 416-480-5775

Administrative Assistant: Karen Fan
Phone: 416-480-6100, ext. 83725
Email: karen.fan@sunnybrook.ca

Education:

  • BPHE, 1996, physical and health education, Laurentian University, Canada
  • M.Sc., 1999, exercise science, Syracuse University, U.S.
  • PhD, 2006, neuroscience, Western University, Canada

Appointments and Affiliations:

  • Scientist, Evaluative Clinical Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute
  • Core member, Heart & Stroke Foundation Canadian Partnership for Stroke Recovery
  • Adjunct scientist, Toronto Rehabilitation Institute-University Health Network
  • Assistant professor (status appointment), department of physical therapy, faculty of medicine, University of Toronto
  • Full member, Rehabilitation Sciences Institute, School of Graduate Studies, U of T

Research Foci:

  • Stroke
  • Hypertonicity
  • Neuromotor control
  • Balance

Research Summary:

The overall goal of Dr. Mochizuki’s research is to develop strategies for reversing the changes in neuromotor control of movement that occur after stroke. The first objective is to examine and characterize systematically the changes in brain and muscle properties that occur after stroke, and to identify the impact that stroke-induced neuromotor uncoupling has on the ability to perform functional tasks. The second objective is to use the knowledge of the brain and muscle changes that occur after stroke to develop novel combinatory neurotherapeutics (such as magnetic or electrical stimulation with physical therapy) to facilitate motor recovery.

The research focuses on pursuing these objectives in the context of post-stroke spasticity in the upper and lower limbs. Techniques used in the research include electroencephalography (EEG), intramuscular single motor unit and surface electromyography (EMG), transcranial magnetic stimulation (TMS) and robotics.

Selected Publications:

  1. Phadke CP, Ismail F, Boulias C, Gage W, Mochizuki G. The impact of post-stroke spasticity and Botulinum toxin on standing balance: a systematic review. Expert Rev Neurother. 2014;14(3):319–327.
  2. Singer JC, Mansfield A, Danells CJ, McIlroy WE, Mochizuki G. The effect of post-stroke lower-limb spasticity on the control of standing balance: interlimb spatial and temporal synchronization of centres of pressure. Clin Biomech (Bristol, Avon). 2013 Oct;28(8):921–926.
  3. Mochizuki G, Boe S, Marlin A, McIlroy WE. Perturbation-evoked cortical activity reflects both the context and consequence of postural instability. Neuroscience. 2010 Oct;170(2):599–609.
  4. Garland SJ, Ivanova TD, Mochizuki G. Recovery of standing balance and health-related quality of life after mild or moderate stroke. Arch Phys Med Rehabil. 2007 Feb;88(2):218–227.
  5. Mochizuki G, Ivanova TD, Garland SJ. Synchronization of motor units in human soleus muscle during standing postural tasks. J Neurophysiol. 2005 Jul; 94(1):62–69.

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