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Scientist profiles S-Z

SRI Profiles

Bradley Strauss, MD, PhD

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room A2 53
Toronto, ON
M4N 3M5

Phone: 416-480-6066

Senior Administrative Assistant: Tasneem Dalal
Phone: 416-480-4975
Email: tasneem.dalal@sri.utoronto.ca

Education:

  • B.Sc., 1978, University of Toronto, Canada
  • MD, 1982, University of Toronto, Canada
  • Fellow (health professional), 1987, internal medicine, Royal College of Physicians and Surgeons of Canada, Canada
  • Fellow (health professional), 1988, cardiology, Royal College of Physicians and Surgeons of Canada, Canada
  • PhD, 1991, medicine, Erasmus University, Netherlands

Appointments and Affiliations:

  • Senior scientist, Biological Sciences, Schulich Heart Research Program, Sunnybrook Research Institute
  • Professor, department of medicine, University of Toronto
  • Professor, laboratory medicine and pathobiology, University of Toronto
  • Reichmann Chair, cardiovascular sciences, Sunnybrook Health Sciences Centre and University of Toronto
  • Director, interventional cardiology research, Sunnybrook Health Sciences Centre

Research Foci:

  • Restenosis after coronary interventions
  • Evaluation of new coronary devices and imaging modalities
  • Pathophysiology and new therapies for treating chronic total occlusions

Research Summary:

Dr. Strauss is involved in the following research studies:

  • Importance of extracellular matrix proteins in the vessel wall response to injury
  • Role of matrix metalloproteinases (MMPs) and elastases in vessel wall repair
  • New approaches to inhibiting collagen synthesis and accumulation after balloon angioplasty and stenting
  • Angiographic restenosis after human stenting and lasers, and new risk factors for restenosis
  • Novel approach to performing angioplasty in chronic total occlusions

Selected Publications:

See current publications list at PubMed.

  1. Ronen Jaffe R, Thierry Charron T, Geoffrey Puley G, Alexander Dick A, Strauss BH. Microvascular Obstruction and the No-Reflow Phenomenon Following Percutaneous Coronary Intervention: Update for the Clinician. Circulation 2008; 117(24):3152-6
  2. Courtney BK, Munce NR, Anderson K, Thind A, Leung G, Roberts N, Radau P, Foster FS, Vitkin IA, Schwartz RS, Dick AJ, Wright GA, Strauss BH. Innovations in Imaging for Chronic Total Occlusions. Eur Heart J 2008;29(5):583-93
  3. Jaffe R, Leung G, Munce NR, Thind AS, Leong-Poi H, Anderson KJT, Trogadis J, Nadler A, Shiff D, Saperia J, Qiang B, Teitelbaum A, Dick AJ, Sparkes JD, Butany J, Wright GA, Strauss BH. Natural History of Experimental Arterial Chronic Total Occlusions. J Am Coll Cardiol 2009 In press
  4. Wong AP, Jackson ZA, Nili N, Leong-Poi H, Qiang B, LeClerc Y, Ranaani E, Strauss BH. Positive Remodeling in Venous Bypass Grafts: Novel Implications toward Vein Graft Failure. Atherosclerosis 2008;196:580-9
  5. Cheema AN, Hong T, Nili N, Segev A, Moffat JG , Lipson KE, Howlett AR, Holdsworth DW, Cole M, Qiang B, Kolodgie F, Virmani R, Stewart DJ, Strauss BH. Adventitial Angiogenesis: A novel mechanism of in-stent restenosis and inhibitory effects of SU11218, a tyrosine kinase inhibitor. J Am Coll Cardiol 2006; 47(5):1067-75

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