Scientist Profiles S-Z

Sunnybrook Research Institute

Greg Stanisz PhD

Senior Scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S6 56
Toronto, ON
M4N 3M5


Phone: 416-480-5725
Fax: 416-480-5714

Administrative Assistant: Janet Binding
Phone: 416-480-4293
Email: janet.binding@sunnybrook.ca

Education:

  • PhD, 1990, Physics, Jagellonion University, Poland

Appointments and Affiliations:

  • Senior scientist, imaging - brain sciences program, Sunnybrook Research Institute
  • Associate professor, medical physics, department of medical biophysics, University of Toronto

Research Summary:

Magnetic resonance imaging (MRI) proved to be a very useful and spectacular diagnostic tool that allows to image soft tissue non-invasively. Measured MRI signal characteristics depends on the physical and chemical processes experienced by water molecules in tissues. Our work involves studies that quantitatively characterize the MRI signal behaviour in various types of normal and pathological tissues in order to obtain information about tissue microstructure. Quantitative MRI can be used to estimate physical tissue parameters such as: cell dimensions, cell membranes permeabilities, translational and rotational motion of water in different tissue compartments (intra- and extracellular).

Current research involves measuring basic MR properties of neural tissue at 1.5, and 3T and developing tissue multi-compartmental models is order to correlate experimental data with quantitative tissue histopathology. We are particularly interested whether NMR measurements such as T1, T2 relaxation times, diffusion and Magnetization Transfer between water and macromolecules can be used to evaluate the processes of neural tissue degeneration and regeneration following trauma and stroke. We are also studying the efficacy of MRI techniques in monitoring stem cell therapies in spinal cord injury and stroke.

Selected Publications:

See current publications list at PubMed.

  1. Stanisz GJ & Henkelman RM, Diffusional Anisotropy of T2 Components in Bovine Optic Nerve Magn.Reson.Med. 40, 405-410, (1998)
  2. Stanisz GJ, Kecojevic A, Bronskill MJ, Henkelman RM, Characterizing White Matter with Magnetization Transfer and T2 Relaxation, Magn.Reson.Med. 42:1128-1136 (1999)
  3. Henkelman RM, Stanisz GJ, Graham SJ, Magnetization Transfer in MRI: A Review NMR in Biomed. 14:57-64 (2001)
  4. Stanisz GJ, Midha R, Munro CA, Henkelman RM, MR properties of rat sciatic nerve following trauma Magn.Reson.Med. 45:415-420 (2001)
  5. Stanisz GJ, Yoon R, Joy M, Henkelman RM, Why does MTR change with neural depolarization?, Magn Reson Med MRM 47:472-475 (2002)

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