Medicine Care Team
Dr. Andrew Lim MD, FRCPC
Division of neurology
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room M1 600
416-480-6100, ext. 2461
Administrative Assistant: Richelle Bercasio
Phone: 416-480-6100 ext. 2461
- B.Sc., 1999, microbiology and immunology, University of British Columbia, Canada
- MD, 2003, University of Toronto, Canada
- FRCPC, 2008, adult neurology, Royal College of Physicians and Surgeons of Canada
- Diploma in electroencephalography, 2008, Canadian Society of Clinical Neurophysiologists
- Clinical fellowship, 2009, sleep medicine, Harvard University, U.S.
- MMSc, 2011, clinical investigation, Harvard University, U.S.
Appointments and Affiliations:
- Sleep and circadian biology
- Noninvasive ambulatory monitoring of sleep and circadian rhythms
- Genetic epidemiology of sleep and circadian traits
- Impact of sleep and circadian function on cognitive decline, dementia and neurodegenerative diseases
Dr. Lim's research is focused on using genetic, neuropathological, and epidemiological approaches to understand better the genes and neural circuits that regulate individuals' biological clocks and their sleep, and how disruption of sleep and biological rhythms (as seen in conditions such as insomnia, shift-work and jet-lag, among others) impact individuals' risks for such common medical disorders as Alzheimer's disease, Parkinson's disease, heart disease and stroke. Dr. Lim has a particular interest in using novel mathematical approaches to infer sleep and circadian function from long-term ambulatory physiological recording techniques such as actigraphy, and is involved in several large cohort studies, including the Ontario Health Study and the Rush Memory and Aging Project.
See current publications list at PubMed.
- Lim AS, Kowgier M, Yu L, Buchman AS, Bennett DA. Sleep fragmentation and the risk of Alzheimer Disease. Sleep. Published online Jan. 11, 2013 www.journalsleep.org/AcceptedPapers/SP-372-12.pdf
- Lim AS, Chang AM, Shulman JM, Raj T, Chibnik LB, Cain SW, Rothamel K, Benoist C, Myers AJ, Czeisler CA, Buchman AS, Bennett DA, Duffy JF, Saper CB, De Jager PL. A common polymorphism near PER1 and the timing of human behavioral rhythms. Ann Neurol. 2012 Sep;72(3):324–34.
- Lim AS, Yu L, Costa MD, Leurgans SE, Buchman AS, Bennett DA, Saper CB. Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. Sleep. 2012 May; 35:633–640.
- Lim AS, Moro E, Lozano AM, Hamani C, Dostrovsky JO, Hutchison WD, Wennberg RA, Lang AE, and Murray BJ. Selective enhancement of REM sleep by deep brain stimulation of the human pons. Ann Neurol. 2009 Jul; 66:110–114.
- Lim AS, Lozano AM, Moro E, Hamani C, Hutchison WD, Dostrovsky JO, Lang AE, Wennberg RA, Murray BJ. Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons. Sleep. 2007 Jul; 30:823–827.
Related News and Stories:
- Making the cut: Amid fiscal challenges, SRI researchers get funded, Feb. 7, 2013
- Are you an early riser or a night owl? Check your DNA, Radio Canada International, Dec. 20, 2012
- Gene determines early risers, time of death, Cosmos Magazine, Nov. 27, 2012
- Genes may predict when you'll die: researchers, CTV News, Nov. 26, 2012
- University of Toronto professor discovers gene that predicts time of death, The Toronto Star, Nov. 19, 2012
- Scientists stimulate dreaming sleep for the first time PDF, Sunnybrook News, Sep. 30, 2009
- Sleep research wakes up to clinical relevance PDF, Neurology Today, Nov. 6, 2007
- Brain waves of dreaming sleep found for first time PDF, Sunnybrook News, July 13, 2007