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Neuropathology

Neuropathology at Sunnybrook is a diverse and rich practice supporting the full spectrum of clinical, research and educational initiatives of Sunnybrook's Hurvtiz Brain Sciences Program.  We work in close collaboration with and offer diagnostic support to the CNS site group of the Odette Cancer Centre and are engaged at weekly multidisciplinary CNS tumour conference.  We specialize in the handling and interpretation of neuromuscular biopsies and neurodegenerative autopsies and enjoy partnership with the Cognitive Neurology and ALS teams at Sunnybrook.

Julia KeithBorn in Halifax, Dr Julia Keith obtained her MD from Dalhousie University in 2003.  She undertook her FRCPC in Neuropathology at the University of Western Ontario (completed 2008) and pursued a fellowship in Neuropathology at the University of Western Australia in Perth, Australia. Dr Keith worked at l'Université de Montréal (CHU Sainte-Justine) before moving to Toronto to become the Director of Neuropathology at Sunnybrook Health Sciences Centre in 2010.  Her academic interests include Education and she is an Assistant Professor and Residency Program Director in Neuropathology at the University of Toronto and the coordinator of the National Neuropathology Lecture Series, a Canadian Post-Graduate and Continuing Medical Educational curriculum in Neuropathology. Research interests include neurodegenerative and neuromuscular Neuropathology.

Julia Keith MD, FRCPC
Neuropathologist
Department of Anatomical Pathology
Sunnybrook Health Sciences Centre
2075 Bayview Avenue
Toronto, Ontario
M4N 3M5
Phone: 416-480-6100 x 88055
Fax: 416-480-4271
julia.keith@sunnybrook.ca

Selected recent publications:

Zhang M, Xi Zhengrui, Zinman L, Bruni AC, Maletta RG, Curcio SAM, Rainero I, Rubino E, Pinessi L, Nacmias B, Sorbi S, Galimbert D, Lang AE, Fox S, Surace EI, Ghani M, Guo J, Sato C, Moreno D, Liang Y, Keith J, Traynor BJ, St George-Hyslop P, Rogaeva E. Mutation analysis of CHCHD10 in different neurodegenerative diseases. Brain, in press

Nafisi H, Cesari M, Karamchandani J, Baluslabrum G, Keith J. Metastatic ovarian carcinoma of the brain: an approach to recognition and classification for neuropathologists. Neuropathology. 2014 Nov. doi: 10.1111/neup.12172. [Epub ahead of print]

Tsang DS, Khan L, Perry JR, Soliman H, Sahgal A, Keith JL, Mainprize TG, Das S, Zhang L, Tsao MN. Survival outcomes in elderly patients with glioblastoma. Clin Oncol. doi: 10.1016/j.clon.2014.11.026. [Epub ahead of print]

Alturkustani M, Keith J, Hazrati LN, Rademakers R, Ang LC. Pathologic staging of white matter lesions in adult-onset leukoencephalopathy/leukodystrophy with axonal spheroids. J Neuropathol Exp Neurol. 2015 Mar;74(3):233-40.

Keith JL, Bilbao J, Croul S, Ang LC, Guiot MC, Rossiter J, Ghorab Z, Hawkins C, Karamchandani J. Clinical Neuropathology practice guide 6-2013: morphology and an appropriate immunohistochemical screening panel aid in the identification of synovial sarcoma by neuropathologists. Clin Neuropathol. 2013 Nov-Dec;32(6):461-70.

Steriade C, Day GD, Lee L, Murray B, Keith J. LGI1 autoimmune encephalitis presenting as cerebellar degeneration. Journal Neuropathology and Applied Neurobiology. Neuropathol Appl Neurobiol. 2014 Aug;40(5):645-9.

Ng J, Celebre A, Munoz D, Keith J, Karamchandani J. Sox10 is Superior to S100 in the Diagnosis of Meningioma. Applied Immunohistochemistry & Molecular Morphology. 2014 Feb. In Press.

Sahgal A, Ironside S, Perry J, Mainprize T, Keith J, Laperriere N, Tsao M, Paszat L. Factors influencing overall survival specific to adult low-grade astrocytoma (LGA): A population-based study. Clinical Oncology. 2013 Jul;25(7):394-9.

Orlov D, Keith J, Rosen D, Croul S, Kraeva N, Riazi S. Analysis of histomorphology in malignant hyperthermia-susceptible patients. Can J Anaesth. 2013 Oct;60(10):982-989.

Au K, Bilbao J, Mainprize T, Schwartz M, Keith J. Oligodendrogliomas with abundant Refractile Eosinophilic Granular Cells. Can J Neurol Sci. 2013 Sep;40(5):746-8.

Au K, Black SE, Bilbao JB, Masellis M, Keith J. FTLD: Updated Pathology and Co-Existing Neurodegenerative Phenomena in a Cohort of 52 Patients. Mod Pathol. 2013; 26: 414A.

Au K, Black SE, Masselis M, Bilbao JB, Keith J. Mesial temporal sclerosis in FTLD: an association with age, cerebrovascular disease and TDP43. Neurology. 2013; 80 (P05:100).

Mitchell S, Black SE, Rogaeva E, Bilbao J, Keith J. Co-existing glioneuronal tauopathy as a potential explanation for semantic variant primary progressive aphasia phenotype in FTLD-TDP43 harmonized type A. Neurology. 2013; 80 (P05:124).

Xi Z, Zinman L, Moreno D, Schymick J, Liang Y, Sato C, Zheng Y, Ghani M, Dib S, Keith J, Robertson J, Rogaeva E. Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion. Am J Hum Genet. 2013 May: S0002-9297(13)0017.

Munoz D, Rogaeva E, Zinman L, Young B, Masellis M, Black S, Robertson J, Keith J, Bilbao J. Genetic, clinical and pathological associations of TDP43pathy with cerebellar p62 inclusions. J Neuropathol Exp Neurol 2012 71:547-600.

Gao F, Noor R, Keith J, Nadeau Y, Kiss A, Black SE. Relationship between collagenosis of the deep medullary veins and periventricular WMH on MRI in Alzheimer's disease: Does one size fit all? Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2012 July 8(4Supplement): 297.

Keith J, Fabian VA, Walsh P, Charles A, Robitaille Y. Neuropathological homology in true Galloway-Mowat syndrome. J Child Neurology2011. 26(4): 510-7.

Keith J, Bilbao J, Baskind R. JC virus granular neuronopathy and rhombencephalic progressive multifocal leukoencephalopathy: case report and review of the literature. Neuropathology. 2011 10:1440-1789.

Keith J, Zinman L, Cohen S, Young B, Bilbao JM. Paraspinal myopathy with shard-like compact aggregates of thin filaments. Muscle Nerve. 2011 44(1):145-6.

Keith J, Afshar-Ghotli Z, Roussev R, Ernst B, Young B, Bilbao JM. Myopathy as the initial manifestation of primary amyloidosis. Can J Neurol Sci. 2011. 38: 161-164.

Xiao H, Sanelli T, Dib S, Sheps D, Findlater J, Keith J, Bilbao J, Zinman L, Rogaeva E, Robertson J. RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS. Mol Cell Neurosci. 2011. 47(3):167-80.

Keith J, Ang LC. PSP: a review of co-existing neurodegeneration. Can J Neurol Sci. 2008 35: 602-8.

Keith J, Ang LC. Progressive Supranuclear Palsy: clinicopathologic correlation between tau burden, co-existing neurodegeneration and cognitive status. Can J Neurol Sci. 2007 34: 501.

Location and contact

Department of anatomic pathology

Sunnybrook Health Sciences Centre
2075 Bayview Avenue,
E-wing, 4th floor, room E4-32
Toronto, ON M4N 3M5

Phone: 416-480-6100 ext. 4600
Fax: 416-480-4271
anatomic.pathology @sunnybrook.ca