Important information about ranitidine

Health Canada issued a statement last week informing Canadians that the impurity N-nitrosodimethylamine (NDMA) has been detected in some ranitidine drugs, and as a result, has requested that companies marketing ranitidine products in Canada stop distribution until evidence is provided that they do not contain NDMA above acceptable levels.

Ranitidine is available in Canada over-the counter (under the brand name Zantac, or various generics), and by prescription (various generics). Over-the-counter ranitidine is approved to prevent and relieve heartburn associated with acid indigestion and sour stomach. Prescription ranitidine drugs are used to reduce stomach acid for the treatment and prevention of various conditions, such as ulcers of the stomach and intestines, and gastroesophageal reflux disease (commonly known as GERD).

NDMA is considered a probable human carcinogen, meaning it may increase the risk of cancer with long-term exposure to levels above what is considered safe. We are all exposed to low levels of NDMA in some foods such as meats, dairy products and some vegetables, as well as in drinking water. NDMA is not expected to cause harm when ingested at very low levels.

If you are taking ranitidine, please contact your family doctor or pharmacist for a safe alternative. Please do not stop taking ranitidine if it was prescribed to you until you speak to a health care provider.

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