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OPTIMUM: Optimizing outcomes of treatment-resistant depression in older adults

Treatment-resistant depression is a common health problem for older adults. Making it worse is a lack of evidence-based treatments. The OPTIMUM study is examining the risks and benefits of different antidepressant medications and how aging can affect these risks and benefits. This study aims to provide the evidence that older adults need to get effective treatment that works best for them to improve quality of life while minimizing risks. Eligible participants are randomized to one of three medication strategies. The team will assess side effects and mood by phone every other week. Geriatric psychiatrists that are part of the study will provide medication recommendations to the primary care physician of participants.