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SRI Profiles

Richard Aviv, MBChB, MRCP, FRCR

Affiliate scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room AG 31
Toronto, ON
M4N 3M5

Phone: 416-480-4372
Fax: 416-480-5218

Administrative Assistant: Linda Gargaro
Phone: 416-480-6100, ext. 2363


  • MBChB, 1993, University of Cape Town, South Africa
  • MRCP, 1996, Royal College of Physicians, U.K.
  • FRCR, 2001, Royal College of Radiologists, U.K.
  • FRCPC, 2012, Royal College of Physicians, Canada
  • Diplomate, 2013, American Board of Radiology, U.S.

Appointments and Affiliations:

Research Foci:

  • Computed tomography and magnetic resonance perfusion and permeability imaging
  • Cognition in multiple sclerosis
  • Intracranial hemorrhage animal model
  • In vivo study of angiogenesis and tumor response

Research Summary:

Dr. Aviv's principal areas of research are investigating multiple sclerosis and stroke using advanced computed tomography (CT) and magnetic resonance imaging (MRI). Ongoing research activities include:

  • exploring the link between cortical perfusion and cognition in multiple sclerosis (MS)
  • comparative perfusion techniques in MS
  • perfusion as a surrogate of cortical disease severity in MS
  • prospective study of CT permeability as a predictor of hemorrhagic transformation
  • study of image reconstruction algorithms for CT dose reduction
  • computational models of CT perfusion thresholds for predicting tissue fate
  • study exploring vascular etiology in MS using magnetic resonance perfusion markers of disease severity as surrogate markers of disease burden and correlation with cognitive impairment
  • CT angiography "spot sign" predicting primary hematoma expansion
  • STOP-IT Study (spot sign for predicting and treating intracerebral hemorrhage growth), investigating the effect of recombinant factor 7 on hematoma
  • study of spot sign in intracerebral hemorrhage (SPOTLIGHT; co-principal investigator, steering committee member and study radiologist)
  • collaborative study of angiogenesis in primary brain tumors
  • collaborative projects studying prediction of metastasis response to stereotactic radiotherapy using MRI dynamic susceptibility contrast and permeability imaging.

Selected Publications:

See current publications list at PubMed

  1. Huynh TJ, Aviv RI, Dowlatshahi D, Gladstone DJ, Laupacis A, Kiss A, Hill MD, Molina CA, Rodriguez-Luna D, Dzialowski I, Silva Y, Kobayashi A, Lum C, Boulanger JM, Gubitz G, Bhatia R, Padma V, Roy J, Kase CS, Symons SP, Demchuk AM. Validation of the 9-point and 24-point hematoma expansion prediction scores and derivation of the PREDICT A/B scores. Stroke. Epub 2015 Oct 13. doi: 10.1161/STROKEAHA.115.009893.
  2. Blacquiere D, Demchuk AM, Al-Hazzaa M, Deshpande A, Petrcich W, Aviv RI, Rodriguez-Luna D, Molina CA, Silva Blas Y, Dzialowski I, Czlonkowska A, Boulanger JM, Lum C, Gubitz G, Padma V, Roy J, Kase CS, Bhatia R, Hill MD, Dowlatshahi D. Intracerebral hematoma morphologic appearance on noncontrast computed tomography predicts significant hematoma expansion. Stroke. Epub 2015 Oct 8. doi: 10.1161/STROKEAHA.115.010566.
  3. Francis PL, Chia TL, Jakubovic R, O'Connor P, Lee L, Feinstein A, Aviv RI. Extensive white matter dysfunction in cognitively impaired patients with secondary-progressive multiple sclerosis. AJNR Am J Neuroradiol. 2014 Oct;35(10):1910–5.
  4. Aviv RI, Huynh T, Huang Y, Ramsay D, Van Slyke P, Dumont D, Asmah P, Alkins R, Liu R, Hynynen K. An in vivo, MRI-integrated real-time model of active contrast extravasation in acute intracerebral hemorrhage. AJNR Am J Neuroradiol. 2014 Sep;35(9):1693–9.
  5. Jakubovic R, Sahgal A, Ruschin M, Pejovic-Milic A, Milwid R, Aviv RI. Non tumor perfusion changes following stereotactic radiosurgery to brain metastases. Technol Cancer Res Treat. 2014 Aug;14(4):497–50.

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