Research  >  About SRI  >  Scientist Profiles
Share:  
|
PAGE
MENU

Scientist profiles G-L

SRI Profiles

Marc Jeschke, MD, PhD, FACS, FRCSC

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room D704
Toronto, Ontario
M4N 3M5

Phone: 416-480-6703
Fax: 416-480-6763

Administrative Assistant: Susan Kurtz
Email: susan.kurtz@sunnybrook.ca

Education:

  • MD, 1994, Eberhard-Karls-Universitat Tübingen, Germany
  • Master of medical science, 1999, Graduate School of Biomedical Science, University of Texas Medical Branch, U.S.
  • PhD (habitation), 2002, experimental surgery, Universität Regensburg, Germany

Appointments and Affiliations:

Research Foci:

  • Burn
  • Trauma
  • Stress response
  • Inflammation
  • Hypermetabolism, including insulin resistance
  • Cell regeneration
  • Gene transfer
  • Stem cells

Bio:

Show/hide details

Dr. Marc Jeschke has been caring for burn patients and conducting research in the field of burns for nearly 20 years. He is a global leader in burn care, research and education; according to Expertscape, he is the second highest-ranked expert in burns in the world. Dr. Jeschke was appointed director of the Ross Tilley Burn Centre at Sunnybrook Health Sciences Centre in 2010. He is a surgeon-scientist and a professor in the departments of surgery and immunology at the University of Toronto.

The contributions of Dr. Jeschke’s research are numerous and encompass all aspects of burn care and treatment. Specifically, he changed treatment of metabolic and inflammatory responses after burn injury, poor or excessive scarring and production of tissue engineered skin. Recently, Dr. Jeschke broadened his research spectrum to study long-term outcomes and quality of life after burn. These contributions have led to changes in standard of care throughout the world in burn patients and patients with complex wounds.

Dr. Jeschke has a continuous commitment to scholarly work, with more than 350 peer-reviewed articles, books and book chapters on burn care. Service to the profession is evident from many years of active membership in organizations like the Society for Critical Care Medicine, American Burn Association, Surgical Infection Society, Shock Society, American College of Surgeons and the American Surgical Association. He serves on numerous committees and editorial boards and is a reviewer for funding agencies including the Canadian Institutes of Health Research, National Institutes of Health and the U.S. Department of Defense. His reputation extends beyond burns as an invited speaker nationally and internationally.

He has won numerous awards that are given to individuals with outstanding productivity, as shown by publication record, grants held and students trained. Among others, distinctions include the Fellow Award from the American Surgical Association Foundation in 2008, the Marvin Tile Distinguished Service Award from Sunnybrook in 2011 and the George Armstrong-Peters Prize from the University of Toronto in 2013. He has been funded continuously since 2000 and has a significant track record of successes with federal funding agencies and private foundations. He has a total lifetime funding of over $20,000,000 as principal or co-investigator. Dr. Jeschke has an essential role in worldwide multicenter clinical trials and is engaged in multiple ongoing multicentre trials.

Another hallmark of Dr. Jeschke’s career is education. Dr. Jeschke has an established training program and has mentored more than 100 MD, PhD and other graduate students in the field of burn care and research. In the spring of 2017, he received the Excellence in Education Award: Educating Beyond Sunnybrook. The effectiveness of Dr. Jeschke as an educator can be assessed by his students’ success in winning highly competitive federal awards and grants, national research competitions, prizes and leadership positions.

Research Summary:

Show/hide details

Burn is a severe trauma to patients inducing various responses in the body such as stress, inflammation, hypermetabolism, catabolism and alterations in the entire glucose, fat and amino acid equilibrium. Cells are undergoing major stress and die, thus compromising organ function. The source of the stress is most likely the burned area inducing these detrimental changes via several signals and mediators. The goal of Dr. Jeschke’s research is to attenuate stress hypermetabolic and catabolic responses, and improve cell regeneration and survival. His team is studying the stress-induced changes in the liver and various other tissues at a cellular and cell organelle level in an attempt to identify key signalling molecules and pathways that may be altered to improve cell survival and organ function.

The Jeschke lab also studies various potential perturbations to improve the cellular stress response, which can be rapidly implemented in the clinical arena. The group also studies new techniques to cover the wounds of a severely burned patient, not only with the patient's own skin, but also using adult stem cells.

Overall, the research focus of his laboratory is to improve morbidity and mortality of severely injured trauma patients, like burn patients, and to identify major modulating aspects of these responses.

Selected Publications:

See current publications list at PubMed.

  1. Auger C, Sivayoganathan T, Abdullahi A, Parousis A, Jeschke MG. Hepatic mitochondrial bioenergetics in aged C57BL/6 mice exhibit delayed recovery from severe burn injury. Biochim Biophys Acta. 2017 Jul 12. pii: S0925-4439(17)30230–2.
  2. Finnerty CC, Jeschke MG, Branski LK, Barret JP, Dziewulski P, Herndon DN. Hypertrophic scarring: the greatest unmet challenge after burn injury. Lancet. 2016 Oct 1;388(10052):1427–36.
  3. Abdullahi A, Jeschke MG. White adipose tissue browning: a double-edged sword. Trends Endocrinol Metab. 2016 Aug;27(8):542–52. Review.
  4. Jeschke MG, Abdullahi A, Burnett M, Rehou S, Stanojcic M. Glucose control in severely burned patients using metformin: an interim safety and efficacy analysis of a Phase II randomized controlled trial. Ann Surg. 2016 Sep;264(3):518–27.
  5. Stanojcic M, Chen P, Xiu F, Jeschke MG. Impaired immune response in elderly burn patients: new insights into the immune-senescence phenotype. Ann Surg. 2016 Jul;264(1):195–202.

Related News and Stories:

Related Links: