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SRI Profiles

Marc Jeschke, MD, PhD, FACS, FRCSC

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room D704
Toronto, Ontario
M4N 3M5

Phone: 416-480-6703
Fax: 416-480-6763

Administrative Assistant: Susan Kurtz
Email: susan.kurtz@sunnybrook.ca

Education:

  • MD, 1994, Eberhard-Karls-Universitat Tübingen, Germany
  • Master of medical science, 1999, Graduate School of Biomedical Science, University of Texas Medical Branch, U.S.
  • PhD (habilitation), 2002, experimental surgery, Universität Regensburg, Germany

Appointments and Affiliations:

  • Senior scientist, Biological SciencesTory Trauma Research Program, Sunnybrook Research Institute (SRI)
  • Chair in Burn Research, SRI
  • Director, Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre
  • Professor, division of plastic and reconstructive surgery, department of surgery, University of Toronto
  • Professor, department of immunology, U of T
  • Faculty, Institute of Medical Science, U of T

Research Foci:

  • Burn
  • Trauma
  • Stress response
  • Inflammation
  • Hypermetabolism, including insulin resistance
  • Cell regeneration
  • Gene transfer
  • Stem cells

Bio:

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Dr. Marc Jeschke has been caring for burn patients and conducting research in the field of burns for nearly 20 years. He is a global leader in burn care, research and education; according to Expertscape, he is the second highest-ranked expert in burns in the world. Dr. Jeschke was appointed director of the Ross Tilley Burn Centre at Sunnybrook Health Sciences Centre in 2010. He is a surgeon-scientist and a professor in the departments of surgery, and immunology at the University of Toronto.

The contributions of Dr. Jeschke’s research are numerous and encompass all aspects of burn care and treatment. Specifically, he changed treatment of metabolic and inflammatory responses after burn injury, poor or excessive scarring and production of tissue-engineered skin. Recently, Dr. Jeschke broadened his research spectrum to study long-term outcomes and quality of life after burn. These contributions have led to changes in standard of care throughout the world in burn patients and patients with complex wounds.

Dr. Jeschke has a continuous commitment to scholarly work, with more than 350 peer-reviewed articles, books and book chapters on burn care. Service to the profession is evident from many years of active membership in organizations like the Society for Critical Care Medicine, American Burn Association, Surgical Infection Society, Shock Society, American College of Surgeons and the American Surgical Association. He serves on numerous committees and editorial boards, and is a reviewer for funding agencies, including the Canadian Institutes of Health Research, National Institutes of Health and the U.S. Department of Defense. His reputation extends beyond burns as an invited speaker nationally and internationally.

He has been recognized based on leadership, productivity, grants held and students trained. Most recently, Dr. Jeschke was elected a Fellow of the Canadian Academy of Health Sciences. Other accolades include the Lister Prize from the University of Toronto (2018); the Excellence in Education Award: Educating Beyond Sunnybrook (2017); the Leo N. Steven Excellence in Leadership Award (2017); the George Armstrong-Peters Prize from the University of Toronto (2013); the Marvin Tile Distinguished Service Award from Sunnybrook (2011); and the Fellow Award from the American Surgical Association Foundation (2008).

He has been funded continuously since 2000, and has a significant track record of success with federal funding agencies and private foundations. He has a total lifetime funding of over $20 million as principal or co-investigator. Dr. Jeschke has an essential role in participating in worldwide multicentre clinical.

Another hallmark of Dr. Jeschke’s career is education. He has an established training program and has mentored well over 100 MD, PhD and other graduate students in the field of burn care and research. The effectiveness of Dr. Jeschke as an educator can be assessed by his students’ success at winning highly competitive federal awards and grants, national research competitions, prizes and leadership positions.

Research Summary:

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Burn is a severe trauma to patients inducing various responses in the body such as stress, inflammation, hypermetabolism, catabolism and alterations in the entire glucose, fat and amino acid equilibrium. Cells are undergoing major stress and die, thus compromising organ function. The source of the stress is most likely the burned area inducing these detrimental changes via several signals and mediators. The goal of Dr. Jeschke’s research is to attenuate stress hypermetabolic and catabolic responses, and improve cell regeneration and survival. His team is studying the stress-induced changes in the liver and various other tissues at a cellular and cell organelle level to identify key signalling molecules and pathways that may be altered to improve cell survival and organ function.

The Jeschke lab also studies various potential perturbations to improve the cellular stress response that can be rapidly implemented in the clinical arena. They also study new techniques to cover the wounds of a severely burned patient, not only with the patient's own skin, but also using adult stem cells.

Overall, the research focus of his laboratory is to improve morbidity and mortality of severely injured trauma patients, like burn patients, and to identify major modulating aspects of these responses.

Selected Publications:

See current publications list at PubMed.

  1. Jeschke MG, Abdullahi A, Burnett M, Rehou S, Stanojcic M. Glucose control in severely burned patients using metformin: an interim safety and efficacy analysis of a Phase II randomized controlled trial. Ann Surg. 2016 Sep;264(3):518–27.
  2. Xiu F, Stanojcic M, Wang V, Qi P, Jeschke MG. C-C chemokine receptor type 2 expression on monocytes before sepsis onset is higher than that of postsepsis in septic burned patients: a new predictor for sepsis in burned injury. Ann Surg. 2016 Aug;264(2):392–8.
  3. Stanojcic M, Chen P, Xiu F, Jeschke MG. Impaired immune response in elderly burn patients: new insights into the immune-senescence phenotype. Ann Surg. 2016 Jul;264(1):195–202.
  4. Jeschke MG, Patsouris D, Stanojcic M, Abdullahi A, Rehou S, Pinto R, Chen P, Burnett M, Amini-Nik S. Pathophysiologic response to burns in the elderly. EBioMedicine. 2015 Jul 31;2(10):1536–48.
  5. Patsouris D, Qi P, Abdullahi A, Stanojcic M, Chen P, Parousis A, Amini-Nik S, Jeschke MG. Burn induces browning of the subcutaneous white adipose tissue in mice and humans. Cell Rep. 2015 Nov 24;13(8):1538–44.

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