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SRI Profiles

Hagen Benjamin Klieb

Affiliate scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room H1 26
Toronto, ON
M4N 3M5

Phone: 416-480-6100, ext. 2438
Fax: 416-480-5757

Administrative Assistant: Cristeen Lee
Phone: 416-480-6100, ext. 89143


  • HBSc, 2001, biology, University of Toronto, Canada
  • DMD, 2005, DMD, McGill University, Canada
  • MSc, 2009, University of Toronto, Canada
  • Oral medicine and oral pathology, 2009, University of Toronto, Canada

Appointments and Affiliations:

  • Affiliate scientist, Evaluative Clinical Sciences, Integrated Community Research Program, Sunnybrook Research Institute
  • Clinician, departments of dentistry and anatomic pathology (cross appointed), Sunnybrook Health Sciences Centre

Research Foci:

  • Oral cancer
  • Management of oral muco-cutaneous disease

Research Summary:

The focus of Dr. Klieb’s research is precancerous oral lesions, and in particular, pathways for malignant transformation. He is also interested in novel modalities to optimize the management of oral muco-cutaneous disease.

Selected Publications:

See current publications list at PubMed.

  1. Guillaud M, MacAulay CE, Berean KW, Bullock M, Guggisberg K, Klieb H, Puttagunta L, Penner C, Kwan K, Rosin MP, Poh CF. Using quantitative tissue phenotype to assess the margins of surgical samples from a pan-Canadian surgery study. Head Neck. 2018 Jun;40(6):1263­–1270. doi: 10.1002/hed.25106. [Epub 2018 Feb 16]
  2. Liu KYP, Lu XJD, Cheng YL, Klieb H, Ng S, McNeil K, Karsan A, Poh CF. An actionable test using loss of heterozygosity in identifying high-risk oral premalignant lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Dec 18. pii: S2212–4403(17)31208–7. doi: 10.1016/j.oooo.2017.10.019. [Epub ahead of print]
  3. Lai J, Blanas N, Higgins K, Klieb H. Ameloblastic fibrosarcoma: report of a case, study of immunophenotype and comprehensive review of the literature. J Oral Maxillofac Surg. 2012 Aug;70(8):2007–12. doi: 10.1016/j.joms.2011.09.012. [Epub 2011 Dec 16]
  4. Antonescu CR, Katabi N, Zhang L, Sung YS, Seethala RR, Jordan RC, Perez-Ordoñez B, Have C, Asa SL, Leong IT, Bradley G, Klieb H, Weinreb I. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011 Jul;50(7):559–70. doi: 10.1002/gcc.20881. [Epub 2011 Apr 11]
  5. Klieb H and Raphael S. Comparative study of the expression of p53, Ki67, E-cadherin and MMP-1 in verrucous hyperplasia and verrucous carcinoma of the oral cavity. Head Neck Pathol. 2007 Dec;1(2):118–122. doi: 10.1007/s12105-007-0029-y. [Epub 2007 Oct 26]

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