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Scientist profiles M-R

SRI Profiles

Ori Nevo, MD

Scientist

Sunnybrook Health Sciences Centre
2075 Bayview Avenue, Room M4 134
Toronto, ON
M4N 3M5

Phone: 416-480-4920
Fax: 416-480-4933

Administrative Assistant: Cindy Yancu
Phone: 416-480-4920
Email: cindy.yancu@sunnybrook.ca

Clinical Work:

  • Full-time maternal fetal medicine specialist (high-risk pregnancy) with a focus on fetal medicine and early fetal ultrasound in the Sunnybrook DAN Women & Babies Program, division of maternal fetal medicine
  • Head of the Sunnybrook Centre for Early Fetal Ultrasound
  • Co-medical director, Obstetrical Ultrasound Centre, Sunnybrook Health Sciences Centre

Education:

  • MD, 1991, Hebrew University, Israel
  • Residency, 2003, department of obstetrics and gynecology, Rambam Medical Center, Israel
  • MFM Fellowship, 2006, maternal and fetal medicine, obstetrics and gynecology, University of Toronto, Canada

Appointments and Affiliations:

Research Focus:

  • Maternal endothelial function in normal pregnancy and in preeclampsia
  • Developing a placental liquid biopsy based on maternal circulating extracellular vesicles
  • Pro and anti-angiogenic signalling during normal placentation and in preeclamptic/intrauterine growth restriction pregnancies
  • Detection of fetal anomalies by early transvaginal anatomy scan

Selected Publications:

See current publications list at PubMed.

  1. Stratulat V, Melamed N, Barrett J, Nevo O, Hack K, Ronzoni S. Validation of upsilon (Y) zone as pathognomonic ultrasound landmark for chorionicity and amnionicity in triplet pregnancy at any gestational age. Ultrasound Obstet Gynecol. 2021 Mar;57(3):501-503.
  2. Lee DK, Nevo O. Tumor necrosis factor alpha expression is increased in maternal microvascular endothelial cells in preeclampsia. Hypertens Pregnancy. 2021 May 12:1-9.
  3. Simula N, Brown R, Butt K, Morency AM, Demers S, Grigoriu A, Nevo O. Committee Opinion No. 418: The Complete 11-14 Week Prenatal Sonographic Examination. J Obstet Gynaecol Can. 2021 May 17:S1701-2163(21)
  4. Ermini L, Farrell A, Alahari S, Ausman J, Park C, Sallais J, Melland-Smith M, Porter T, Edson M, Nevo O, Litvack M, Post M, Caniggia I . Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction. Front Cell Dev Biol. 2021 May 4;9:652651.
  5. Mirdamadi K, Kwok J, Nevo O, Berger H, Piquette-Miller M, Impact of Th-17 Cytokines on the Regulation of Transporters in Human Placental Explants. M.Pharmaceutics. 2021 Jun 15;13(6):881.
  6. Lim KI, Butt K, Nevo O, Crane JM. Guideline No. 401: Sonographic Cervical Length in Singleton Pregnancies: Techniques and Clinical Applications. J Obstet Gynaecol Can. 2020 Nov;42(11):1394-1413.
  7. Mei-Dan E, Hutchison Z, Osmond M, Pakenham S, Ng E, Green J, Nevo O. Preterm Premature Rupture of Membranes in Twins: Comparison of Rupture in the Presenting Versus Non-presenting Sac. J Obstet Gynaecol Can. 2020 Feb;42(2):163-168.
  8. Hiersch L, Okby R, Freeman H, Rosen H, Nevo O, Barrett J, Melamed N. Differences in fetal growth patterns between twins and singletons. J Matern Fetal Neonatal Med. 2019 Feb 3:1-10.
  9. Butt K, Crane J, Hutcheon J, Lim K, Nevo O. Universal Cervical Length Screening. J Obstet Gynaecol Can. 2019 Mar;41(3):363-374.
  10. Van den Hof MC, Smithies M, Nevo O, Oullet A. Clinical Practice Guideline on the Use of First Trimester Ultrasound. J Obstet Gynaecol Can. 2019 Mar;41(3):388-395.
  11. Lee D, Sengupta A, Nevo O. The effect of magnesium sulfate on maternal microvascular endothelial cells. Hypertens Pregnancy. 2018 Feb; 37(1):30-36.
  12. Nevo O, Brown R, Glanc P, Lim K. Technical Update: The role of Early Comprehensive Fetal Anatomy Ultrasound Examination. J Obstet Gynaecol Can. 2017 Dec. 39(12):1212-1220.
  13. Shea AK, Simpson AN, Barrett J, Ladhani N, Nevo O. Pregnancy Outcomes of Women Admitted to a Tertiary Care Centre with Short Cervix. J Obstet Gynaecol Can. 2017 May;39(5):328-334.
  14. Lee DK, Nevo O. Microvascular endothelial cells from preeclamptic women exhibit altered expression of angiogenic and vasopressor factors. Am J Physiol Heart & Circulatory. 2016 Jun 1;310(11):H1834-41.
  15. Xu J, Sivasubramaniyam T, Yinon Y, Tagliaferro A, Ray J, Nevo O, Post M, Caniggia I. Aberrant TGFβ Signalling Contributes to Altered Trophoblast Differentiation in Preeclampsia. Endocrinology. 2016 Feb; 157(2):883-99.
  16. Rosen H, Barrett J, Okby R, Nevo O, Melamed N. Risk factors for obstetric anal sphincter injuries in twin deliveries: a retrospective review. Int Urogynecol J. 2016 May;27(5):757-62.
  17. Rosen H, Melamed N, Okby R, Nevo O, Barrett J. Is the risk of obstetric anal sphincter injuries increased in vaginal twin deliveries. J Matern Fetal Neonatal Med. 2016; 29(10):1700-3.
  18. Lee DK, Nevo O. 2-Methoxyestradiol regulates VEGFR-2 and sFlt-1 expression in human placenta. Placenta, 2015;36(2):125-30.

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