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SRI Profiles

Dr. Chao Wang.
Chao Wang, PhD

Scientist
Assistant Professor

Sunnybrook Health Sciences Centre
2075 Bayview Ave., room S113
Toronto, ON
M4N 3M5

Phone: 416-480-6100 x1903

Administrative assistant: Cassandra Cheng
Phone: 416-480-6100 x3537
Email: cassandra.cheng@sunnybrook.ca

Education:

  • B.Sc. Honours, 2004, Simon Fraser University, Canada
  • PhD, 2011, Immunology, University of Toronto, Canada
  • Postdoctoral fellow, 2012, Immunology, University of Toronto, Canada
  • Postdoctoral fellow, 2016, Neurology, Brigham and Women’s Hospital and Harvard Medical School, USA

Appointments and Affiliations:

  • Scientist, Biological Platforms, Odette Cancer Research Program, Sunnybrook Research Institute
  • Assistant Professor, Department of Immunology, University of Toronto

Research Foci:

  • Establishment of immune tolerance to CNS
  • Transcriptomic and epigenomic regulation of metabolic network
  • Neurological disorders

Research Summary:

The immune system plays a dynamic role in the progression of neurological disorders such as neurodegeneration and major depression. My lab focuses on understanding the regulation of immune cells in the central nervous system at steady state and during neuroinflammation in such context.

Metabolism provides a critical link between environment and host genetics. My lab takes a systems and cell biology approach to investigate metabolic circuitry and its connection with epigenome and transcriptome regulation of immune cells with consequences in their function.

The Wang lab is interested in clinically relevant research and strives to create a highly collaborative environment for training multidisciplinary scientists at all levels.

Selected Publications:

See current publications list.

  1. Wang C, Wagner A, Fessler J, Avila-Pacheco J, Karminski J, Thakore P, Zaghouani S, Pierce K, Bod Lloyd, Schnell A, DeTomaso D, Ron-Harel N, Haigis M, Puleston D, Pearce E, Soleimani M, Sobel R, Clish C, Regev A, Yosef N, Kuchroo VK. Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway. 2019. Submitted. Preprints available at BioRxiv: https://doi.org/10.1101/2020.01.23.911966 
  2. Wagner A*, Wang C*, DeTomaso D, Avila-Pacheco J, Zaghouani S, Fessler J, Akama-Garren E, Pierce K, Ron-Harel N, Douglas VP, Haigis M, Sobel RA, Clish C, Regev A, Kuchroo VK, Yosef N. In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity. 2019. Submitted. Preprints available at BioRxiv: https://doi.org/10.1101/2020.01.23.912717. *Joint first authors
  3. Wang C, Singer M, Anderson AC. Molecular Dissection of CD8+ T-cell dysfunction. Trends in Immunology. 2017. PMID: 28662970 
  4. Singer M*, Wang C*, Cong L, Marjanovic ND, Kowalczyk MS, Zhang HY, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JYH, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK+, Regev A+. Anderson AC+ A distinct gene module uncouples dysfunction from activation in tumor-infiltrating T cells. Cell. 2016. 2016. 166(6): 1500. PMID: 27610572. *Joint first authors
  5. Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish C, Kaminski J, Xiao S, Zu Horste GM, Pawlak M, Kishi Y, Karwacz K, Zhu C, Ordovas M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A Kuchroo VK. CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity. Cell. 2015. 163(6): 1413. PMID: 26607793.