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Hurvitz Brain Sciences Program

SRI Programs

Jamie Near
Jamie Near, PhD

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S6-60
Toronto, ON
M4N 3M5

Phone: 416-480-6826

Administrative assistant: Jennifer Chen
Phone: 416-480-4678
Email: Jennifer.chen@sunnybrook.ca

Education:

  • Sc., 2004, engineering physics, Queen’s University, Canada
  • PhD, 2009, medical biophysics, University of Western Ontario, Canada
  • Postdoc, 2012, Oxford University, UK

Appointments and Affiliations:

  • Scientist, physical sciences, Hurvitz Brain Sciences Program, Sunnybrook Research Institute
  • Associate professor, department of medical biophysics, University of Toronto

Research Foci:

  • Magnetic Resonance Spectroscopy
  • Brain chemistry and metabolism
  • Alzheimer’s disease, aging

Research Summary:

Altered brain chemistry and metabolism are in fact key features of many neurological and neuropsychiatric conditions. These alterations can be assessed non-invasively using in vivo magnetic resonance spectroscopy (MRS), a technique closely related to MRI.

Jamie’s research is focused on:

  1. developing new MRS techniques for characterizing brain chemistry and metabolism, and
  2. applying these tools towards the study of mental health and brain disorders in both humans and rodent models of disease.

The goal of Jamie's research is to develop a better understanding of the underlying neurochemistry of brain health and disease, leading to improved therapy and prevention of brain disorders.

Selected Publications:

See current publications list at PubMed.

  1. Dehghani M, Zhang S, Kumaragamage C, Rosa-Neto P, Near J. Dynamic 1 H-MRS for detection of 13 C-labeled glucose metabolism in the human brain at 3T. Magn reson med. 2020; 84(3): 1140-1151.
  2. Fowler CF, Madularu D, Dehghani M, Devenyi GA, Near J. Longitudinal quantification of metabolites and macromolecules reveals age- and sex-related changes in the healthy Fischer 344 rat brain. Neurobiol aging. 2020; 101: 109-122.
  3. Goerzen D, Fowler C, Devenyi GA, Germann J, Madularu D, Chakravarty MM, Near J. An MRI-Derived Neuroanatomical Atlas of the Fischer 344 Rat Brain. Sci rep. 2020; 10(1): 6952.
  4. Near J, Harris AD, Juchem C, Kreis R, Marjańska M, Öz G, Slotboom J, Wilson M, Gasparovic C. Preprocessing, analysis and quantification in single-voxel magnetic resonance spectroscopy: experts' consensus recommendations. NMR biomed. 2020; 34(5): e4257.
  5. Simpson R, Devenyi GA, Jezzard P, Hennessy TJ, Near J. Advanced processing and simulation of MRS data using the FID appliance (FID-A)-An open source, MATLAB-based toolkit. Magnetic resonance in medicine 2017; 77(1): 23-33.

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