Hurvitz Brain Sciences

SRI Programs

Trung Le, MD, PhD, FRCSC

Associate scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room M1 102
Toronto, ON
M4N 3M5


Administrative Assistant: Jennifer Nguyen
Phone: 416-480-4141
Email: jennifer.nguyen@sunnybrook.ca
Fax: 416-480-5761

Education:

  • B.Sc., 2001, microbiology, University of Manitoba, Canada
  • MD-PhD, 2010, Faculty of Medicine, and department of biochemistry and medical genetics, University of Manitoba
  • Residency, 2015, otolaryngology, head and neck surgery, University of Manitoba
  • Research and clinical fellowship, 2016, otology/neurotology and lateral skull base surgery, University of British Columbia, Canada
  • Clinical fellowship, 2017, otology/neurotology and lateral skull base surgery, University of Toronto, Canada

Appointments and Affiliations:

  • Associate scientist, Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute
  • Assistant professor, department of otolaryngology—head & neck surgery, U of T
  • Otologist/neurotologist, Sunnybrook Health Sciences Centre
  • Associate member, Institue of Medical Science, U of T

Research Foci:

  • Stem cell and gene therapy
  • Magnetic targeting delivery
  • Cochlear implantation
  • Blood-labyrinth barrier
  • Neurodevelopmental biology

Research Summary:

Sensorineural hearing loss is one of the most common disabilities in society and sets in place a gradual but ongoing degeneration of hair cells and auditory nerves of the cochlea. Hair cells help convert sound (acoustic) energy into neural (electrical) signals, which then travel via the auditory nerve to the brain where sound is interpreted. Injury to any part of this information highway will lead to irreversible hearing loss. The overall goal of Dr. Le's research is to develop therapeutic interventions that will regenerate this auditory pathway and restore normal hearing to those affected with hearing loss. The three specific aims of his laboratory include the following:

  • investigating different techniques of magnetic targeting as a therapeutic delivery method to the cochlea;
  • applying stem cell and gene therapy for regeneration of hair cells and auditory neurons;
  • and studying the permeability of blood-labyrinth barrier of the inner ear.

Selected Publications:

See current publications list at PubMed.

  1. Le TN, Straatman LV, Yanai A, Rahmanian R, Cathy Garnis, Urs Häfeli, Poblete T, Westerberg B, Gregory-Evans K. Magnetic stem cell targeting to the inner ear. J Magn Magn Mater. 2017 Dec 1;443:385–396.
  2. Le TN, Straatman LV, Lea J, Westerberg B. Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options. J Otolaryngol Head Neck Surg. 2017 May;46(1):41.
  3. Bhimrao SK, Le TN, Dong CJ, Serge M, Wongprasartsuk S, Westerberg BD, Akagami R. Role of facial nerve motor-evoked potential ratio in predicting facial nerve function in vestibular schwannoma surgery both immediate and at one year. Otol Neurotol. 2016 Sep;37(8):1162–7.
  4. Le TN, Du G, Fonseca M, Zhou QP, Wigle JT, Eisenstat DD. DLX homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2. J Biol Chem. 2007 Jun;282(26):19071–81.
  5. Zhou QP, Le TN, Qiu X, Spencer V, Plews M, de Melo J, Du G, Fonseca M, Sun JM, Davie J, Eisenstat DD. Identification of Dlx homeodomain targets in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation. Nucleic Acids Res. 2004 Feb;32(3):884–92.