Trial details

Trial short name: PERIOP-06

Official title: A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver

Principal Investigator: Dr. Paul Karanicolas

Cancer type: Gastrointestinal
Cancer location: Liver
Disease stage: Advanced Cancer
Trial phase: Phase 2
Intervention: Drug: QBECO, Drug: Placebo

Registration #: NCT05677113

Contact e-mail: cancerclinicaltrials@sunnybrook.ca

Trial description:
The goal of this type of clinical trial is t to answer the following question: Can the chance of colorectal cancer progressing be lowered by taking a medication, QBECO, before and after surgery? The goal of this study is to find out if this approach is better or worse than the standard of care for your type of cancer. The standard of care is defined as care most people get for metastatic colorectal cancer. There is currently no standard of care drug being given before or after surgery to prevent further spread of your cancer. Participants will be asked to self-inject the study medication before surgery for minimum of 11 days and after surgery for minimum of 41 days. Participants will be followed up every 3 months for 2 years, with a final visit at year 5.

Inclusion Criteria: • Adults aged 18 years or older at time of enrollment. • Pathologic diagnosis of colorectal carcinoma with clinical diagnosis of liver metastases • Planned to undergo resection of liver lesions for complete clearance of all visible metastatic disease. This will include those who may undergo synchronous resection of the primary colorectal cancer and/or those who may receive a combination of surgery and ablation to treat all lesions. • Computerized Tomography (CT) of the chest, abdomen, and pelvis with intravenous (IV) contrast within 6 weeks prior to enrollment. • MRI of the liver within 6 weeks prior to enrollment OR within 6 weeks prior to starting neoadjuvant chemotherapy (for patients treated with chemotherapy). • Planned to receive the last dose of neoadjuvant chemotherapy at least 25 days prior to surgery (for patients treated with neoadjuvant chemotherapy). • Agree to comply with the contraceptive requirements of the protocol when applicable • Willing and able to either perform subcutaneous injections according to the study protocol, or receive the injections from a caregiver delegated by the participant. • Able to provide informed consent or has a substitute decision maker capable of providing consent on their behalf. Exclusion Criteria: • Prior or current evidence of extrahepatic metastases. Patients with small (<1.0 cm) indeterminate pulmonary nodules may be included at the investigator's discretion. • Prior hepatic arterial infusion or embolization. Prior portal vein embolization, ablation, or liver resection are permitted. • Patients with any invasive cancer history other than colorectal cancer in the last 5 years. In situ disease (e.g., melanoma in situ, ductal carcinoma in situ of the breast) or non melanoma skin cancers are permitted. • Patients with a documented history of clinically severe autoimmune disease or a syndrome that requires systemic steroids or immunosuppressive agents. This includes patient requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalent, or depot corticosteroids in the 6 weeks before enrollment) or immunosuppressant drugs (such as azathioprine, tacrolimus, cyclosporine, etc.) within the 14 days prior to enrollment or a reasonable expectation that the patient may require such treatment during the course of the study. Inhaled or topical or inter-articular steroids, and adrenal replacement steroid doses ≤ 10 mg daily prednisone equivalent, are permitted in the absence of active autoimmune disease. Steroids used for premedication prior to chemotherapy or as part of a chemotherapy regimen are allowed. • Patients with known active human immunodeficiency virus (HIV), Hepatitis B, or Hepatitis C infections. • Pregnant patients or those who are nursing an infant