3.b.ii.2 Adenocarcinoma In Situ Intestinal-type

Andenocarcinoma in situ Intestinal type

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The intestinal type variant of adenocarcinoma in situ (AIS) of the cervix is less common than the conventional endocervical AIS. The intestinal type of AIS can also be under-recognised because it can show only minimal nuclear stratification, crowding, hyperchromasia or mitotic activity, which are the usual diagnostic features of the conventional endocervical AIS. Identification of goblet cells in variable amount is the key feature to establish the diagnosis. The origin of intestinal differentiation in the endocervix remains uncertain. Nevertheless, immunohistochemical studies have shown that these lesions represent true intestinal differentiation, as demonstrated by their positivity for CDX2.

Reference:
Saad RS, Nofech-Mozes S, Ismiil N, Dubé V, Khalifa MA. CDX-2 Expression is a Common Event in Primary Intestinal-Type Endocervical Adenocarcinoma. Am J Clin Pathol. 132(4): 531-8. 2009 Oct).