3.b.iii.2 Invasive Mucinous Adenocarcinoma Intestinal-type

Invasive Mucinous Adenocarcinoma Intestinal type

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Invasive adenocarcinoma of intestinal type is a rare variant of endocervical adenocarcinoma which is also HPV related. It is believed to arise from intestinal type adenocarcinoma in situ. The diagnostic criteria for invasion are similar to that of the conventional mucinous endocervical adenocarcinoma, but the characteristic feature of the intestinal type is the presence of goblet cells. Intestinal differentiation is also confirmed by the immunohistochemical phenotype; most cases (>80%) are positive for CDX2 and many (>20%) are also positive for CK20.

Reference:
Saad RS, Ismiil N, Dubé V, Nofech-Mozes S, Khalifa MA. CDX-2 expression is a common event in primary intestinal-type endocervical adenocarcinoma. Am J Clin Pathol. 2009 Oct;132(4):531-8.