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Hospital  >  Departments  >  Laboratory Medicine  >  Anatomic Pathology  >  Gynecologic Pathology   >  Image Atlas  >  Cervix  >  3.0 Malignant and pre-malignant lesions  >  3.a.iii.3 Lymphoepithelioma-Like Variant
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3.a.iii.3 Lymphoepithelioma-Like Variant

Click to enlarge image of Lymphoepithelioma-like Variant Click to enlarge image of Lymphoepithelioma-like Variant Click to enlarge image of Lymphoepithelioma-like Variant

Lymphoepithelioma-like Variant

Lymphoepithelioma-like Variant

Lymphoepithelioma-like Variant


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Lymphoepithelioma-like carcinoma of the cervix is an uncommon variant of poorly differentiated non-keratinizing squamous cell carcinoma. Its morphology is similar to that of the nasopharyngeal lymphoepithelioma-like carcinoma. Malignant cells show abundant eosinophilic cytoplasm with large nuclei and prominent nucleoli. The cellular borders are indistinct, which confers a syncytial appearance. The carcinoma is accompanied by an intense inflammatory reaction. The main differential diagnosis is lymphoma: identification of cohesive cellular clusters and positive immunohistochemical staining for p63 or cytokeratin 5/6 usually easily confirm the diagnosis. Epstein-Barr virus DNA has been identified in some cases in the Asian population, but only rarely in the western population. Therefore, the role of EBV in the pathogenesis of lymphoepithelioma-like carcinoma is uncertain and there might be geographical variations. The role of human papilloma virus infection also remains unclear.

Contact Information

Gynecologic Pathology
Room E-436,
2075 Bayview Avenue,
Toronto, Ontario
M4N 3M5

Admin. Assistant/Clerical Supervisor

Lesley Nicholson
lesley.nicholson@
sunnybrook.ca

Tel: 416-480-4009