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Hospital  >  Departments  >  Laboratory Medicine  >  Molecular Diagnostics
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Molecular Diagnostics

Please see our Molecular Diagnostics Requisition form for a full menu of current in-house somatic (cancer) and germline (hereditary) molecular testing available. To order an in-house molecular test, please fill out this requisition and deliver to Sunnybrook Hospital, room E410 along with the sample. If the test is being requested on a sample that has already been reported or received by the laboratory, please fax the requisition to x4271.

Molecular Pathology (Somatic Cancer Testing)

In molecular pathology, our laboratory is focused on DNA diagnostic testing for solid tumors and hematological diseases, including:

  • B-cell and T-cell clonality on blood, bone marrow and tissue specimens
  • JAK2 and CALR mutations in chronic myeloid lymphoma
  • Human papillomavirus studies on liquid-based gynecological cytology specimens of patients at-risk for developing cervical cancer
  • EGFR mutations in lung cancers
  • BRAF mutations in melanoma
  • eRAS and MSI mutations in colorectal cancers

Molecular Genetics (Germline Hereditary Testing)

The Molecular Diagnostics laboratory actively support clinical testing and research in human genetics and molecular medicine.

We offer clinical genetics tests including:

  • Factor V Leiden and Prothrombin 20210A
  • common mutations in the hemochromatosis (HFE) gene
  • common mutations in the thiopurine methyltransferase (TPMT) gene
  • HLA-B*5701 genotyping for abacavir hypersensitivity

For information about Genetic testing, visit the Genetic Testing Registry (GTR).

Molecular Microbiology

Our laboratory uses PCR-based methods for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae and the confirmation of vancomycin-resistant Enterococcus (VRE) isolated in cultures.

If inquiring about testing services for research, method development or educational purposes, please contact Dr. Weei-Yuarn Huang, the Medical Director at weeiyuarn.huang@sunnybrook.ca or the laboratory manager at samuel.matsumura@sunnybrook.ca or the laboratory supervisor at betty.wong@sunnybrook.ca