Odette Cancer Centre and Sunnybrook Research Institute Oncology Grand Rounds

Dr. Meaghan O’Reilly, PhD

Senior Scientist, Physical Sciences, Sunnybrook Research Institute
Associate Professor, Department of Medical Biophysics, University of Toronto
Canada Research Chair in Biomedical Ultrasound, Tier 2

Topic: Developing Focused Ultrasound as a Treatment for Leptomeningeal Metastases

Objectives:

1. To review non-thermal mechanisms of focused ultrasound (FUS) in the CNS
2. To present on-going work in rodent models of leptomeningeal metastases
3. To discuss clinical scale translation of technology for spine targeted FUS

Dr. Kasia Jerzak, MD, MSc, FRCPC

Medical Oncologist, Sunnybrook Odette Cancer Centre
Assistant Professor, Department of Medicine, University of Toronto
Associate Scientist, Evaluative Clinical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute

Topic: Breast Cancer Brain Metastases

Objectives:

1. Discuss the risk of brain metastases among patients with metastatic breast cancer
2. Review the prognosis of patients with metastatic breast cancer and brain metastases
3. Discuss risks/benefits of potential screening for brain metastases

Chao Wang, PhD

Scientist, Biological Sciences, Sunnybrook Research Institute
Canada Research Chair in Immunometabolism of Neuroinflammation (Tier 2)
Assistant Professor, Department of Immunology, University of Toronto

Topic: From checkpoint molecule regulation to metabolic circuitry at single cell resolution

Rosanna Pezo, MD, PhD, FRCPC

Affiliate Scientist, Sunnybrook Research Institute
Assistant Professor, Department of Medicine, University of Toronto
Medical Oncologist, Sunnybrook Odette Cancer Centre

Topic: The role of precision medicine in the treatment of advanced breast cancer

Objectives:

1. Overview of systemic therapy for metastatic breast cancer.
2. Present current clinical research in genomics and precision medication in cancer and ongoing trials.
3. Discuss challenges in identifying targetable alterations and match patients to genotype-matched clinical trials.

Anne L. Martel, PhD

Professor, Medical Biophysics, University of Toronto
Senior Scientist, Imaging Research, Sunnybrook Research Institute
Vector Institute Faculty Affiliate

Topic: "Applications of artificial intelligence in oncology"

Objectives:

1. ​To understand how radiomics can be used to predict outcomes in brain and liver metastases
2. To understand the challenges of applying deep learning methods to digital pathology images
3. To introduce a plan to create an Artificial Intelligence Platform for Precision Medicine at SRI

William Tran, MRT(T), MSc, PhD

Scientist, Biological Sciences Platform, Sunnybrook Research Institute
RT Clinician Scientist
Sunnybrook Health Sciences Centre, Odette Cancer Program
Assistant Professor, Department of Radiation Oncology, University of Toronto

Topic: "Precision Oncology in Breast Cancer Using Artificial Intelligence"

Objectives:

1. Present clinical challenges in breast cancer
2. Review artificial intelligence opportunities in precision breast oncology
3. Present current research in diagnostic and theranostic applications

Iacovos Michael, PhD

Scientist, Biological Sciences, Sunnybrook Research Institute
Assistant Professor, Medical Biophysics, University of Toronto

Topic: "Neuroendocrine tumors: phenotypic plasticity and prospects for precision oncology"

Objectives:

1. ​Role of phenotypic plasticity in pancreatic neuroendocrine tumors
2. Neuroendocrine transdifferentiation of epithelial cancers and brain metastasis
3. Prospects of establishing a NET precision oncology program at Sunnybrook

Sten Myrehaug, MD FRCPC

Affiliate scientist, Sunnybrook Research Institute
Radiation Oncologist, Sunnybrook Odette Cancer Centre
Assistant Professor, Department of Radiation Oncology, University of Toronto

Topic: "Evolution in the Role of Radiation in the Management of Neuroendocrine Tumors"

Objectives:

1. Review current management of Neuroendocrine Malignancies
2. Discuss current radiation oncology strategies for Neuroendocrine Malignancies

Dr. Hon Leong, PhD

Senior Scientist, Biological Sciences
Associate Professor, Department of Medical Biophysics

Topic: "Novel Prostate Cancer Biomarkers to Avoid Pyrrhic Victories in the Clinic"

Objectives:

1. ​Explore the use of AI in liquid biopsy development.
2. Extracellular vesicles as a novel biomarker platform.
3. Evaluate alternate forms of PSA as a biomarker for clinically significant disease.

Dr. Andrew Loblaw, MD FRCPC

Senior Scientist, Sunnybrook Research Institute
Professor, Departments of Radiation Oncology and Health Policy Measurement and Evaluation, University of Toronto
Co-Lead GU Disease Site Group, Odette Cancer Centre

Topic: "Changes in the Diagnosis and Treatment of Prostate Cancer"

Objectives:

1. To review changes in screening recommendations for prostate cancer.
2. To understand the value of MRI in the diagnostic care path.
3. To review advances in radiotherapy for the treatment of primary disease.

Dr. Robert Kerbel, PhD

Senior Scientist, Sunnybrook Research Institute
Professor, Department of Medical Biophysics, University of Toronto

Topic: “A pre-clinical strategy to improve prediction of treatment efficacy in breast cancer patients - what have we learned”

Dr. Eileen Rakovitch, MD MSc FRCPC

Senior Scientist, LC Campbell Chair in Breast Cancer Research, Sunnybrook Research Institute
Professor, Department of Radiation Oncology, University of Toronto
Adjunct Senior Scientist, IC/ES
Program Research Director, Odette Cancer Program

Topic: “The evolving role of genomic biomarkers in the management of ductal carcinoma In situ”