Microscopy and optical imaging

Contact: Brian Wilson wilson@oci.utoronto.ca

Focus

• confocal microscopy and macroscopy
• multi-photon imaging
• near-field microscopy
• CCD-based imaging

Upcoming Proposals in Focus

Multi-modal microscopy platform
Contact: Brian Wilson wilson@oci.utoronto.ca

Impact

Near-term technologies:

Integrate existing fluorescence and multi-photon technologies for applications in neuroscience and cancer detection. This development will focus on the integration of existing technologies and the development of a new femtosecond laser system in Ontario. The result will be a new imaging product and a new laser product, both to be manufactured in Ontario.

Emerging technologies:

• new femtosecond laser development
• real-time macroscopy for large specimens (up to 7 cm in size)
• fluorescence imaging for cancer detection
• cooled CCD-arrays and camera technology
• near-field microscopy
• reporter materials (molecular probes)

Related information management technologies:

• computer tools for comparison of multi-modal images

Potential industrial partners (more are welcome)

• enabling technologies: DALSA, JDS Uniphase, Noriga, S.G.I., Walsh
• integration: Biomedical Photometrics Inc., DMI
• applications: Multiple

Potential participants

• Toronto: Princess Margaret Hospital (Brian Wilson, David Hedley), University of Toronto (Cynthia Goh, Martin Moskovits, Chris Yip, Dwayne Miller), Ryerson (Steven Liss, Derick Rousseau)
• Waterloo: University of Waterloo (Ted Dixon, Melanie Campbell, Eric Jervis)
• Ottawa: Loeb Institute (Peter Stys, Andrew Ridsdale)

Complementary to existing programs

• CFI/ORDCF
• OMA
• TMIC

Budgetary focus of application

Strong emphasis on equipment.

Timescale

Multi-modal microscopy proposal for next ORDCF deadline (May 2000).