Evaluative Clinical Sciences

Education:

• BA, 1956, University of Saskatchewan, Canada
• MD, 1958, University of Saskatchewan, Canada
• FRCP(C), 1963, Internal Medicine, Canada

Appointments and Affiliations:

• Affiliate scientist, Evaluative Clinical Sciences, Schulich Heart Research Program, Sunnybrook Research Institute
• Assistant professor, department of medicine, University of Toronto
• Staff internist, division of cardiology, York Central Hospital

Research Focus:

• Analysis of randomized trials

Research Summary:

Dr. Blakely's background, in addition to being a practicing internist, is in randomized trials. These are the backbone of progress in medical therapeutics, and their performance has improved markedly over the past few decades. Their analysis has not kept pace, and most are analyzed using rituals that were appropriate for simpler problems in simpler times. As trials have become more complex, with events occurring over the course of the trial, and recently by the use of active controls, the problem has become more serious. It is past time that the notion of a ‘statistical’ logic, different from other logic, was put to rest. Dr. Blakely's objective is the development of methods appropriate to the contemporary problems of current trials.

Selected Publications:

See current publications list at PubMed.

1. Blakely JA. The Heart and Estrogen/progestin Replacement Study revisited: Hormone replacement therapy produced net harm, consistent with the observational data. Arch Int Med. 2000;160(19):2897–2900.
2. Blakely JA. Anticoagulation in chronic nonvalvular atrial fibrillation: Appraisal of two meta-analyses. Can J Cardiol. 1998;14(7):945–948.
3. Blakely JA. Clinical trials in stroke: a new approach. In Norris JW, Hachinski VC (eds): Prevention of Stroke. New York: Springer-Verlag, 1991, pp161–170.
4. Bartle WR, Blakely JA. Potentiation of warfarin anticoagulation by acetaminophen. JAMA. 1991;265(10):1260.