Medicine care team

Administrative Assistant: Jeffrey Steer
Phone: 416-480-4494
Email: jeffrey.steer@sunnybrook.ca

Clinical Profile:

In December 2010, Scott Walker was promoted to the position of Director of Pharmacy at Sunnybrook Health Sciences Centre.
Scott obtained his BScPhm from UofT in 1977 and his Master of Science in Pharmacy for UofT in 1980.
Previously Scott held the position of Coordinator of Research & Quality Control in the Department of Pharmacy at Sunnybrook Health Sciences Centre where he managed an analytical lab. The Quality Control lab is widely known by hospital pharmacists for the completion and publication of numerous IV additive stability studies used to support the IV additive service found within hospital pharmacy departments across Canada.
Scott is also cross-appointed as an Associate Professor in the Faculty of Pharmacy at the University of Toronto where he teaches pharmacokinetics to both the PharmD and undergraduate students.

Scott is a fellow of the Canadian Society of Hospital Pharmacists and has received more than 30 awards in the CSHP National Awards competitions over the years. He served as an Associate Editor of CJHP from 1987 until 1992 when he became the Editor of CJHP. Scott served as the editor of CJHP from 1996 to 2007.

Education:

• BScPhm, 1977, University of Toronto, Canada
• MScPhm, 1980, University of Toronto, Canada

Appointments and Affiliations:

• Director of Pharmacy, Sunnybrook Health Sciences Centre
• Associate Professor, Faculty of Pharmacy, University of Toronto
• Federal Health Protection Branch, Working Group on Bioavailablity
• Health Canada Scientific Advisory Committee on Bioavailability and Bioequivalence
• Drug Quality and Therapeutics Committee, Ontario Ministry of Health

Research Focus:

• Drug stability
• Pharmacokinetics and pharmacodynamics of drugs

Research Summary:

Scott Walker's research interests include drug stability in support of the IV-additive program within Sunnybrook Health Sciences Centre as well as the pharmacokinetics and pharmacodynamics of drugs which has resulted in the evaluation of many drug-drug and drug-food interactions. The intent of research in patient and normal volunteers is to address clinically relevant questions and to provide a better understanding of the effects of disease or age on drug disposition; to develop rational population-based dosing guidelines; and to examine the relationship between the serum concentrations of a given drug and therapeutic outcome and/or toxicity.

Publications:

• Scott has more than 110-refereed publications, of which approximately half pertain the drug stability and or drug-drug compatibility.

See current publication list at PubMed

Selected Publications:

Walker SE, Milliken D, Law S. Stability of bortezomib vials reconstituted with 0.9% sodium chloride at 4C and room temperature. Can J Hosp Pharm 2008;61(1):14-20.

Walker SE, Iazzetta J, Law S. Stability Of Pantoprazole In 0.9% Sodium Chloride Injection (NS) at 4C and Room Temperature (24C). Can J Hosp Pharm 2009; 62(2): 135-41.

Friesen MH, Walker SE. Are the current bioequivalence standards sufficient for the acceptance of narrow therapeutic index drugs? Utilization of a computer simulated warfarin bioequivalence model. J Pharm Pharmaceut Sci 1999; 2: 15-22. http://www.ualberta.ca/~csps

Finkelstein Y, Nava-Ocampo A, Schechter T, Grant R, St. Pierre E, Goldman R, Walker S; Koren G. Discrepancies in pharmacokinetic analysis results obtained by using two standard population pharmacokinetics software programs. Fundamental and Clinical Pharmacology 2009; 23(1):53-7.

Draves AH, Walker SE. Determination of hypericin and pseudohypericin in pharmaceutical preparations by liquid chromatography with fluorescence detection. Journal of Chromatography B Biomedical Sciences and Applications 2000; 749: 57-66.

Draves AH, Walker SE. Analysis of the hypericin and pseudohypericin content of commercially available St John's wort preparations. Canadian Journal of Clinical Pharmacology 2003; 10 (3): 114-8.

Shulamn KI, Walker SE. Refining the MAOI diet: tyramine content of Pizzas and soy products. J Clin Psychiatry 1999; 60: 191-3.

Yeung SM, Walker SE, Tailor SAN, Awdishu L, Tobe S, Yassa Y. Pharmacokinetics of oral ciprofloxacin in non-infected patients on continuous cycling peritoneal dialysis. Peritoneal Dialysis International 2004; 24: 447-53.

Edward Mills E, Wilson K, Clarke M, Foster B, Walker SE, Rachlis B, DeGroot N, Gold W, Phillips E, Myers S, Gallicano K. Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis. Eur J Clin Pharmacol 2005; 61: 1-7.

Lathia N, Mittmann N, DeAngelis C, Knowles S, Cheung M, Piliotis E, Shear N, Walker S. Evaluation of Direct Medical Costs of Hospitalization for Febrile Neutropenia. Cancer. 2009 (in press May 2009)