Schulich Heart Program

Education:

• MD, 2002, University of Calgary, Canada
• FRCPC, 2006, internal medicine, University of Toronto, Canada
• FRCPC, 2008, adult cardiology, U of T, Canada
• Interventional cardiology, 2010, Sunnybrook Health Sciences Centre,   U of T, Canada
• Advanced cardiac imaging, 2012, Columbia University, U.S.

Appointments and Affiliations:

• Affiliate scientist, Physical Sciences, Schulich Heart Research Program, Sunnybrook Research Institute
• Interventional cardiologist, Sunnybrook Health Sciences Centre and Michael Garron Hospital (formerly Toronto East General Hospital)
• Assistant professor, department of medicine, U of T
• Head, division of cardiology and medical director of cardiac services, Michael Garron Hospital

Research Foci:

• Cardiac magnetic resonance imaging
• Acute myocardial infarction
• Myocardial inflammation

Research Summary:

The focus of Dr. Zia’s research is delineating myocardial tissue injury using cardiac magnetic resonance imaging post acute myocardial infarction. Cardiac magnetic resonance has gained clinical importance in the noninvasive assessment of myocardial injury post acute myocardial infarction. Myocardial edema, hemorrhage and microvascular obstruction are important parameters of microvascular injury implicated in the remodeling process.

His imaging group has developed and characterized the evolution of myocardial edema and hemorrhage using quantitative T2 and T2* mapping techniques postacute myocardial infarction. This knowledge could help evaluate potential treatment strategies and allow for quantitative imaging parameters to be used as surrogate markers of important clinical outcomes.

Selected Publications:

See current publications list at PubMed.

1. Roifman I, Ghugre NR, Vira T, Zia MI, Zavodni A, Pop M, Connelly KA, Wright GA. Assessment of the longitudinal changes in infarct heterogeneity post myocardial infarction. BMC Cardiovasc Disord. 2016; 16:198.
2. Roifman I, Ghugre NR, Zia MI, Farkouh ME, Zavodni A, Wright GA, Connelly KA. Diabetes is an independent predictor of right ventricular dysfunction post ST-elevation myocardial infarction. Cardiovasc Diabetol. 2016;15:34.
3. Zia MI, Ghugre NR, Connelly KA, Strauss BH, Sparkes JD, Dick AJ, Wright GA. Characterizing myocardial edema and hemorrhage using quantitative T2 and T2* mapping at multiple time intervals post ST-segment elevation myocardial infarction. Circ Cardiovasc Imaging. 2012 Sep 1;5(5):566–72.
4. Zia MI, Ghugre NR, Connelly KA, Joshi SB, Strauss BH, Cohen EA, Wright GA, Dick AJ. Thrombus aspiration during primary percutaneous coronary intervention is associated with reduced myocardial edema, hemorrhage, microvascular obstruction and left ventricular remodeling. J Cardiovasc Magn Reson. 2012 Mar 26;14:19.
5. Zia MI, Valenti V, Cherston C, Criscito M, Uretsky S, Wolff S. Relation of mitral valve prolapse to basal left ventricular hypertrophy as determined by cardiac magnetic resonance imaging. Am J Cardiol. 2012 May 1;109(9):1321–5.
6. Zia MI, Wijeysundera HC, Tu JV, Lee DS, Ko DT. Percutaneous coronary intervention with vs. without on-site cardiac surgery backup: a systematic review and meta-analysis. Can J Cardiol. 2011 Sep–Oct;27(5):664.e9–16.