Evaluative Clinical Sciences

Education:

• B.Sc., 1996, immunology and history, University of Toronto, Canada
• MD, 2000, U of T, Canada
• FRCPC, 2004, internal medicine and infectious diseases, 2006, U of T, Canada
• MPH, 2007, international health, Knox Memorial Fellow, Harvard School of Public Health, U.S.

Appointments and Affiliations:

• Affiliate scientist, Evaluative Clinical Sciences, Veterans Research Program, Sunnybrook Research Institute
• Staff physician, division of infectious diseases, Sunnybrook Health Sciences Centre
• Assistant professor, department of medicine, faculty of medicine; Clinical Public Health and Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health (cross-appointment),      U of T
• Medical advisor, Dignitas International

Research Foci:

• HIV
• Global health

Research Summary:

Dr. Chan’s research focuses on optimizing health services delivery in low resource settings. She has specific interests in decentralization and roll-out of antiretroviral therapy, and HIV-related services in southern Africa. These include:

• HIV program integration with tuberculosis (TB) and non-communicable disease care
• scale up of prevention of mother-to-child transmission services
• task-shifting to address human resources for health constraints.

She is also interested in context-relevant clinical research, which aims to reduce mortality due to opportunistic infections (specifically TB and cryptococcal meningitis) in HIV patients with severe immunosuppression, and in the long term clinical and health systems sequelae of the West Africa Ebola outbreak.

Selected Publications:

See current publications list at PubMed.

1. Chan AK, Kanike E, Bedell R, et al. Same day integration of HIV diagnosis and treatment with antenatal care affects retention in Option B+ prevention of mother-to-child transmission services in Zomba District, Malawi. JIAS. 2016;19:20672.
2. Beardsley J, Wolbers M, Kibengo FM, Kamali A, Cuc NTK, Binh TQ, Chau NVV, Farrar J, Merson L, Phuong L, Thwaites G, Kinh NV, Thuy PT, Chierakul W, Siriboon S, Thiansukhon E, Onsanit S, Supphamongkholchaikul W, Konpan P, Semran K, Chan AK, Heyderman R, Miwnjiwa E, van Oosterhout JJ, Imran D, Basri H, Mayxay M, Dance D, Phimmasone P, Rattanavong S, Lallo DG, Day JN on behalf of CryptoDex Investigators. Adjunctive steroids in HIV-associated cryptococcal meningitis: a randomized controlled trial in African and southeast Asian countries. N Engl J Med. 2016; 374:542–54.
3. Mattia JG, Vandy MJ, Chang JC, Platt DE, Bausch DG, Brooks T, Conteh S, Crozier I, Fowler RA, Kamara AP, Kang C, Mahadevan S, Mansaray Y, Marcell L, McKay G, O’Dempsey T, Parris V, Pinto R, Rangel A, Sala AP, Shantha J, Wolfman V, Yeh S, Chan AK, Mishra S. Early clinical sequelae of Ebola virus disease during convalescence in Sierra Leone. Lancet Infec Dis. 2016;16:331–38.
4. Chan AK, Ford D, Namata H, et al. The Lablite project: a cross-sectional mapping survey of decentralized HIV service provision in Malawi, Uganda and Zimbabwe. BMC Health Services Research. 2014;14:352.
5. Rachlis B, Cole D, van Lettow M, Escobar M, Muula A, Ahmad F, Orbinski J, Chan AK. Follow-up patterns in an antiretroviral therapy programme in Zomba, Malawi. PLoS ONE. 2014;9(7):e101875.

Related News and Stories:

• Ebola Response: Q&A with Dr. Adrienne Chan (Dignitas International, Feb. 27, 2015)
• Evolution of Dignitas International's Global Health Research Program (Dignitas International)

Related Links:

• Dalla Lana School of Publich Health, U of T profile
• Dignitas International
• Institute of Health Policy, Management and Evaluation, U of T profile