Physical sciences

Administrative Assistant: Aneeta Anwarali
Phone: 416-480-4210
Email: aneeta.anwarali@sunnybrook.ca

Education:

• MD, 1984, University of Western Ontario, Canada
• PhD, 1991, Institute of Medical Science, University of Toronto, Canada
• FRCS(C), 1991, general surgery, Canada

Appointments and Affiliations:

• Affiliate scientist, Physical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute
• Surgical oncologist, Sunnybrook Health Sciences Centre
• Associate professor, department of surgery, University of Toronto
• Past chair, research advisory committee, Canadian Breast Cancer Research Alliance
• Provincial clinical lead, disease pathway management and diagnostic assessment programs, Cancer Care Ontario
• Member, breast site committee, program in evidence-based care, Cancer Care Ontario

Research Foci:

• Minimally invasive techniques in the management of breast cancer
• 3-D pathological evaluation of breast specimens
• Optimization of the diagnostic pathway in the evaluation of breast abnormalities
• Use of evidence-based pathways to improve cancer outcomes

Research Summary:

Dr. Holloway's research is focused on the following areas:

Application of 3-D histological evaluation techniques to breast surgery

This work involved the development of a new method to evaluate breast surgical specimens and quantify the improved measurement accuracy of important pathological features using this approach.

Population-based studies

A variety of studies using in-house and provincial databases are ongoing. These studies address such diverse questions as the use of minimally invasive diagnostic techniques to determine indications for breast surgery and define surgical approaches, factors influencing the application of evidence-based guidelines to clinical practice, and the impact of individualized surgical decision-making on patient outcome.

Evaluation of the diagnostic pathway in breast cancer

This work involves population-based retrospective studies, qualitative research and prospective interventions aimed at facilitating the uptake of minimally invasive diagnostic techniques into clinical practice and developing approaches to improve the timeliness and accuracy of diagnostic evaluation.

Selected Publications:

See current publications list at PubMed.

1. Cordeiro E, Dixon M, Coburn N, Holloway CM. A patient-centered approach to wait times in the surgical management of breast cancer in the province of Ontario. Ann Surg Oncol. 2015 Aug;22(8):2509–16.
2. Boileau JF, Poirier B, Basik M, Holloway CM, Gaboury L, Sideris L, Meterissian S, Arnaout A, Brackstone M, McCready DR, Karp SE, Trop I, Lisbona A, Wright FC,, Younan RJ, Provencher L, Patocskai E, Omeroglu A, Robidoux A. Sentinel node biopsy after neoadjuvant chemotherapy in biopsy-proven node-positive breast cancer: the SN FNAC study. J Clin Oncol. 2015 Jan 20;33(3):258–64.
3. Holloway CM, Scollard DA, Caldwell CB, Ehrlich L, Kahn HJ, Reilly RM. Phase I trial of intraoperative detection of tumor margins in patients with HER2-positive carcinoma of the breast following administration of 111In-DTPA-trastuzumab Fab fragments. Nucl Med Biol. 2013 Jul;40(5):630–7.
4. Clarke GM, Murray M, Holloway CM, Liu K, Zubovits JT, Yaffe MJ. 3D pathology volumetric technique: a method for calculating breast tumour volume from whole-mount serial section images. Int J Breast Cancer. 2012;2012:691205.
5. Simpson JS, Ma G, Holloway CMB. Imaging technologies in breast diagnosis and surgical treatment. Minerva Chir. 2011 Oct; 66(5):455–468.

Related News and Stories:

• Cutting to the core of the issue (Sunnybrook Research Institute Research Report, 2002–2004)

Related Link:

• Breast Cancer Research Centre