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SRI Profiles

Mark I. Boulos, B.Sc., MD, FRCP(C), CSCN(EEG), M.Sc.

Associate scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room A4 42
Toronto, ON
M4N 3M5

Phone: 416-480-4473
Fax: 416-480-5753

Administrative Assistant: Ophelia Shen
Phone: 416-480-4473


  • B.Sc., 2002, University of Toronto, Canada
  • MD, 2006, U of T
  • FRCP(C), 2011, adult neurology residency, U of T
  • CSCN(EEG), 2012, Canadian Society of Clinical Neurophysiology, electroencephalography, Canada
  • M.Sc., 2013, stroke and sleep neurology, U of T
  • Clinical research fellowship, 2013, stroke and sleep neurology, U of T

Appointments and Affiliations:

Research Foci:

  • Association of sleep disorders with cerebrovascular disease including:
    • Prevalence, impact and characterization of sleep disorders after transient ischemic attack and stroke
    • Exploring links between various sleep issues, vascular risk factors, incident vascular events and brain imaging
  • Neurophysiological aspects of sleep and cerebrovascular disease (e.g., electroencephalography, eye and limb movement detection)
  • Home and in-hospital sleep monitoring of patients with cerebrovascular disease

Research Summary:

The majority of patients who have sustained a transient ischemic attack (TIA) or stroke complain of sleep-related troubles, or are found to have evidence of a sleep disorder if evaluated using objective measures. Dr. Boulos’ research seeks to explore the prevalence and characteristics of sleep disorders after TIA and stroke.

Dr. Boulos is also investigating the use of portable sleep monitors following a TIA or stroke. He is developing innovative techniques that assess the largest number of patients possible using simple, convenient tools that reliably measure sleep problems such as fragmented sleep, periodic limb movements and obstructive sleep apnea.

Furthermore, Dr. Boulos is studying the association of sleep disorders with brain imaging findings, daytime fatigue and vigilance, cognition, quality of life and incident vascular events.

His research has been funded by the Heart and Stroke Foundation, Canadian Institutes of Health Research, Canadian Stroke Network, Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Academic Health Science Centre Alternative Funding Plan Innovation Fund, and Sunnybrook Education Advisory Council and Education Research Unit.

Selected Publications:

See current publications list at PubMed.

  1. Boulos MI, Murray BJ, Muir RT, Gao F, Szilagyi GM, Huroy M, Kiss A, Walters AS, Black SE, Lim AS, Swartz RH. Periodic Limb Movements and White Matter Hyperintensities in First-Ever Minor Stroke or High-Risk Transient Ischemic Attack. Sleep. 2017 Mar 1;40(3).
  2. Kendzerska T, Kamra M, Murray BJ, Boulos MI. Incident Cardiovascular Events and Death in Individuals With Restless Legs Syndrome or Periodic Limb Movements in Sleep: A Systematic Review. Sleep. 2017 Mar 1;40(3).
  3. Boulos MI, Elias S, Wan A, Im J, Frankul F, Atalla M, Black SE, Basile VS, Sundaram A, Hopyan JJ, Boyle K, Gladstone DJ, Swartz RH, Murray BJ. Unattended hospital and home sleep apnea testing following cerebrovascular events. J Stroke Cerebrovasc Dis. 2017 Jan;26(1):143–149.
  4. Boulos MI, Wan A, Im J, Elias S, Frankul F, Atalla M, Black SE, Basile VS, Sundaram A, Hopyan JJ, Boyle K, Gladstone DJ, Murray BJ, Swartz RH. Identifying obstructive sleep apnea after stroke/TIA: evaluating four simple screening tools. Sleep Med. 2016 May;21:133–9.
  5. Berezuk C, Ramirez J, Gao F, Scott CJM, Huroy M, Swartz RH, Murray BJ, Black SE, Boulos MI. Virchow-Robin spaces in the basal ganglia and white matter: correlations with sleep quality in patients with cerebrovascular disease. Sleep. 2015 Jun 1;38(6):853–8.

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