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Scientist profiles A-F

SRI profiles

Mark I. Boulos, B.Sc., MD, FRCP(C), CSCN(EEG), M.Sc.

Associate scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room A4 55
Toronto, ON
M4N 3M5

Phone: 416-480-4473
Fax: 416-480-5753


  • Sc., 2002, University of Toronto, Canada
  • MD, 2006, U of T
  • FRCPC, 2011, adult neurology residency, U of T
  • CSCN(EEG), 2012, Canadian Society of Clinical Neurophysiology, electroencephalography, Canada
  • Sc., 2013, stroke and sleep neurology, U of T
  • Clinical research fellowship, 2013, stroke and sleep neurology, U of T

Appointments and Affiliations:

Research Foci:

  • Association of sleep disorders with transient ischemic attack (TIA), stroke, dementia/cognitive impairment, and other neurological disorders
  • Neurophysiological aspects of sleep (e.g., electroencephalography, eye and limb movement detection)
  • Home and in-hospital sleep monitoring
  • Establishing normative values for sleep studies.
  • Developing novel approaches to manage sleep disorders

Research Summary:

The majority of patients who have sustained a transient ischemic attack (TIA) or stroke complain of sleep-related troubles, or are found to have evidence of a sleep disorder if evaluated using objective measures. Dr. Boulos’ research seeks to explore the prevalence and characteristics of sleep disorders after TIA and stroke.

Dr. Boulos is also investigating the use of portable sleep monitors following a TIA or stroke. He is developing innovative techniques that assess the largest number of patients possible using simple, convenient tools that reliably measure sleep problems such as fragmented sleep, periodic limb movements and obstructive sleep apnea.

Furthermore, Dr. Boulos is studying the association of sleep disorders with brain imaging findings, daytime fatigue and vigilance, cognition, quality of life and incident vascular events.

Dr. Boulos’ research has been supported by the Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Canadian Partnership for Stroke Recovery, the Innovation Fund of the Academic Health Sciences Centres of Ontario, the Branch Out Neurological Foundation, Ontario Genomics, and several industry partners. In 2020, Dr. Boulos was awarded by the American Academy of Neurology the Wayne Hening Sleep Medicine Investigator Award in recognition of outstanding achievements in Sleep Science research.

Selected Publications:

See current publications list at PubMed.

  1. Boulos MI. The case for improving the detection and treatment of obstructive sleep apnea following stroke. CMAJ. 2023 Mar 14;195(10):E374-E375.
  2. Boulos MI, Kamra M, Colelli DR, Kirolos N, Gladstone DJ, Boyle K, Sundaram A, Hopyan JJ, Swartz RH, Mamdani M, Loong D, Isaranuwatchai W, Murray BJ, Thorpe KE. SLEAP SMART (Sleep Apnea Screening Using Mobile Ambulatory Recorders After TIA/Stroke): A Randomized Controlled Trial. Stroke. 2022 Mar 1;53(3):710-718.
  3. Boulos MI, Dharmakulaseelan L, Brown DL, Swartz RH. Trials in Sleep Apnea and Stroke: Learning From the Past to Direct Future Approaches. Stroke. 2021 Jan 1;52(1):366-372.
  4. Boulos MI, Jairam T, Kendzerska T, Im J, Mekhael A, Murray BJ. Normal polysomnography parameters in healthy adults: a systematic review and meta-analysis. Lancet Respir Med. 2019 Jun 1;7(6):533-543.
  5. Boulos MI, Murray BJ, Muir RT, Gao F, Szilagyi GM, Huroy M, Kiss A, Walters AS, Black SE, Lim AS, Swartz RH. Periodic Limb Movements and White Matter Hyperintensities in First-Ever Minor Stroke or High Risk TIA. Sleep. 2017 Mar 1;40(3).

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