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SRI Profiles

Clement Hamani

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S1 26
Toronto, ON
M4N 3M5

Phone: 416-480-6100, ext. 3318


  • MD, 1993, Federal University of São Paulo, Brazil
  • PhD, 1996, Federal University of São Paulo, Brazil
  • Residency, 2002, neurosurgery, University of São Paulo, Brazil
  • Fellowship, 2008, functional neurosurgery, University of Toronto, Canada

Appointments and Affiliations:

Research Foci:

Research Summary:

The focus of Dr. Hamani’s research is the development of new ways of modulating the function of the nervous tissue, and discovering new applications for techniques that stimulate the brain and spinal cord to treat neurological and psychiatric disorders. His work ranges from basic research in preclinical models to clinical trials.

Selected Publications:

See current publications list at PubMed

  1. Franco RR, Fonoff ET, Alvarenga PG, Alho EJL, Lopes AC, Hoexter MQ, Batistuzzo MC, Paiva RR, Taub A, Shavitt RG, Miguel EC, Teixeira MJ, Damiani D, Hamani C. Assessment of safety and outcome of lateral hypothalamic deep brain stimulation for obesity in a small series of patients with Prader-Willi syndrome. JAMA Netw Open. 2018 Nov 2;1(7):e185275.doi:10.1001/jamanetworkopen.2018.5275.
  2. Rughani A, Schwalb JM, Sidiropoulos C, Pilitsis J, Ramirez-Zamora A, Sweet JA, Mittal S, Espay AJ, Martinez JG, Abosch A, Eskandar E, Gross R, Alterman R, Hamani C. Congress of Neurological Surgeons systematic review and evidence-based guideline on subthalamic nucleus and globus pallidus internus deep brain stimulation for the treatment of patients with Parkinson’s disease: executive summary. Neurosurgery. 2018 Jun 1;82(6):753–56.
  3. Volle J, Bregman T, Scott B, Diwan M, Raymond R, Fletcher PJ, Nobrega JN, Hamani C. Deep brain stimulation and fluoxetine exert different long-term changes in the serotonergic system. Neuropharmacology. 2018 Jun;135:63–72.
  4. Reznikov R, Bambico FR, Diwan M, Raymond RJ, Nashed MG, Nobrega JN, Hamani C. Prefrontal cortex deep brain stimulation improves fear and anxiety-like behavior and reduces basolateral amygdala activity in a preclinical model of post- traumatic stress disorder. Neuropsychopharmacology. 2018 Apr;43(5):1099–1106.
  5. Talakoub O, Paiva RR, Milosevic M, Hoexter MQ, Franco R, Alho E, Navarro J, Pereira JF Jr, Popovic MR, Savage C, Lopes AC, Alvarenga P, Damiani D, Teixeira MJ, Miguel EC, Fonoff ET, Batistuzzo MC, Hamani C. Lateral hypothalamic activity indicates hunger and satiety states in humans. Ann Clin Transl Neurol. 2017 Oct 20;4(12):897–901.

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