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Clement Hamani

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S1 26
Toronto, ON
M4N 3M5

Phone: 416-480-6100 ext. 63318


  • MD, 1993, Federal University of São Paulo, Brazil
  • PhD, 1996, Federal University of São Paulo, Brazil
  • Residency, 2002, neurosurgery, University of São Paulo, Brazil
  • Fellowship, 2008, functional neurosurgery, University of Toronto, Canada

Appointments and Affiliations:

Research Foci:

  • Neuromodulation
  • Functional neurosurgery
  • Neuropsychiatric disorders

Research Summary:

The focus of Dr. Hamani’s research is the development of new ways of modulating the function of the nervous tissue, and discovering new applications for techniques that stimulate the brain and spinal cord to treat neurological and psychiatric disorders. His work ranges from basic research in preclinical models to clinical trials.

Selected Publications:

See current publications list at PubMed

  1. Meng Y, Pople CB, Lea-Banks H, Hynynen K, Lipsman N, Hamani C. Focused ultrasound neuromodulation. Int Rev Neurobiol. 2021;159:221-240. doi:10.1016/bs.irn.2021.06.004.
  2. Hamani C, Fonoff ET, Parravano DC, Silva VA, Galhardoni R, Monaco BA, Navarro J, Yeng LT, Teixeira MJ, de Andrade DC. Motor cortex stimulation for chronic neuropathic pain: results of a double-blind randomized study. Brain. 2021 Nov 29;144(10):2994-3004. doi: 10.1093/brain/awab189
  3. Knotkova H, Hamani C, Sivanesan E, Le Beuffe MFE, Moon JY, Cohen SP, Huntoon MA. Neuromodulation for chronic pain. Lancet. 2021 May 29;397(10289):2111-2124. doi: 10.1016/S0140-6736(21)00794-7.
  4. Hamani C, Davidson B, Levitt A, Meng Y, Corchs F, Abrahao A, Rabin JS, Giacobbe P, Lipsman N. Patient with Posttraumatic Stress Disorder successfully treated with Deep Brain Stimulation of the medial prefrontal cortex and uncinate fasciculus. Biol Psychiatry. 2020 Dec 1;88(11):e57-e59. doi:10.1016/j.biopsych.2020.05.018.
  5. Gouveia FV, Davidson B, Meng Y, Gidyk DC, Rabin JS, Ng E, Abrahao A, Lipsman N, Giacobbe P, Hamani C. Treating Post-traumatic Stress Disorder with Neuromodulation Therapies: Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation, and Deep Brain Stimulation. Neurotherapeutics. 2020 Oct;17(4):1747-1756. doi: 10.1007/s13311-020-00871-0.
  6. Franco RR, Fonoff ET, Alvarenga PG, Alho EJL, Lopes AC, Hoexter MQ, Batistuzzo MC, Paiva RR, Taub A, Shavitt RG, Miguel EC, Teixeira MJ, Damiani D, Hamani C. Assessment of safety and outcome of lateral hypothalamic deep brain stimulation for obesity in a small series of patients with Prader-Willi syndrome. JAMA Netw Open. 2018 Nov 2;1(7):e185275.doi:10.1001/jamanetworkopen.2018.5275.
  7. Reznikov R, Bambico FR, Diwan M, Raymond RJ, Nashed MG, Nobrega JN, Hamani C. Prefrontal cortex deep brain stimulation improves fear and anxiety-like behavior and reduces basolateral amygdala activity in a preclinical model of post- traumatic stress disorder. Neuropsychopharmacology. 2018 Apr;43(5):1099–1106.
  8. Holtzheimer PE, Husain MM, Lisanby SH, Taylor SF, Whitworth LA, McClintock S, Slavin KV, Berman J, McKhann GM, Patil PG, Rittberg BR, Abosch A, Pandurangi AK, Holloway KL, Lam RW, Honey CR, Neimat JS, Henderson JM, DeBattista C, Rothschild AJ, Pilitsis JG, Espinoza RT, Petrides G, Mogilner AY, Matthews K, Peichel D, Gross RE, Hamani C, Lozano AM, Mayberg HS. Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial. Lancet Psychiatry. 2017 Nov;4(11):839-849. doi:10.1016/S2215-0366(17)30371-1.
  9. Hamani C, Temel Y. Deep brain stimulation for psychiatric disease: contributions and validity of animal models. Sci Transl Med. 2012 Jul 11;4(142):142rv8.doi:10.1126/scitranslmed.3003722.
  10. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH. Deep brain stimulation for treatment-resistant depression. Neuron. 2005 Mar 3;45(5):651-60. doi: 10.1016/j.neuron.2005.02.014.

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