Scientist profiles M-R
SRI Profiles
Senior scientist
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S1 13
Toronto, ON
M4N 3M5
Administrative Assistant: Melanie Suttar
Phone: 416-480-6100, ext 3536
Email: melanie.suttar@sri.utoronto.ca
Education:
- B.Sc., 1983, chemistry, Queen’s University, Canada
- M.Sc., 1988, clinical biochemistry, University of Toronto, Canada
- PhD, 1992, clinical biochemistry, U of T, Canada
Appointments and Affiliations:
- Senior scientist, Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute
- Professor, department of laboratory medicine and pathobiology, U of T
- Canada Research Chair in Alzheimer Disease Therapeutics, Tier 1
Research Foci:
- Alzheimer’s disease
- Small molecule therapies
- Stroke and Alzheimer’s disease
- Neurodegeneration
- Vascular risk factors for Alzheimer’s disease
- Neuropsychiatric symptoms in Alzheimer’s disease
Research Summary:
Dr. McLaurin’s research focuses on the development of potential therapeutics to target protein-misfolding disorders, in particular Alzheimer’s disease. Stemming from the basic research of protein-lipid interactions, her laboratory identified a family of naturally occurring compounds that inhibit the formation of toxic soluble aggregates in Alzheimer’s disease. These molecules underwent preclinical studies to demonstrate efficacy and are now being evaluated in Phase II clinical trials. This work is being expanded to examine other neurodegenerative disorders such as amyotrophic lateral sclerosis, Huntington’s disease and Parkinson’s disease to investigate the possibility of a universal anti-aggregant small molecule.
Because amyloid formation and disease progression cannot be monitored at present, her lab is attempting to develop a diagnostic based on compounds that bind amyloid but are not effective therapeutics. The latest endeavours include characterization of novel therapeutics that might be used in combination with small molecule therapies to recover full functioning in patients with Alzheimer’s disease. This work is based on the premise that strategies in clinical trials to date will have some beneficial effects in stabilizing disease progression, yet to achieve optimal cognitive functioning, combination therapies that address other targets will be necessary.
Selected Publications:
See current publications list at PubMed.
- Ma K, McLaurin J. a-Melanocyte stimulating hormone prevents GABAergic cell loss to improve cognition in Alzheimer’s disease. J Neuroscience. 2014;34(20):673–6745.
- Lai AY, Lan C, Hasan S, McLaurin J. scyllo-inositol-induced inhibition of inclusion body formation promotes robust mutant Huntington protein degradation. J Biol Chem. 2014;289:3666–3676.
- Dorr A, Sahota B, Chinta, LV, Lai, AY, Ma K, Brown ME, Hawkes CA, McLaurin J, Stefanovic B. Progressive β-amyloid dependent compromise of microvascular structure and function in Alzheimer’s disease. Brain. 2012;135:3039–3050.
- Hawkes CA, McLaurin J. Cerebral amyloid angiopathy is cleared by perivascular macrophages in the TgCRND8 mouse model of Alzheimer’s disease. Proc Natl Acad Sci USA. 2009:106:1261–1266.
- McLaurin J, Barakat ME, Brown ME, Hawkes CE, Lambermon MHL, Phinney AL, Darabie AA, Cousins JE, French JE, Lan MF, Chen F, Wong SFFN, Mount HTJ, Fraser PE, Westaway DE, St George-Hyslop P. Cyclohexanehexol-based inhibitors of Ab-aggregation prevent and reverse Alzheimer-like features in a transgenic model of Alzheimer disease. Nature Medicine. 2006;12:801–808.
Related News and Stories:
- A meaningful connection: Summer student looks at the role of high blood pressure in the development of Alzheimer's disease (July 12, 2019)
- Three Sunnybrook Research Institute scientists awarded Canada Research Chairs: Drs. JoAnne McLaurin, Meaghan O’Reilly and Bojana Stefanovic recognized with country’s highest research honour (June 17, 2019)
- Resounding approval: Sunnybrook Research Institute's success rate in CIHR competition soars past national average (Jan. 25, 2018)
- Revelling in the rewards of collaboration: A visiting scientist joins forces with Sunnybrook Research Institute faculty to advance research on Alzheimer's disease (Dec. 4, 2017)
- SRI scientists top the national average in successful CIHR project grants: Over a dozen projects approved (June 2, 2017)
- CIHR responds to revolt while releasing results: Peer rebellion brings promise of change to granting agency (July 18, 2016)
- Ask a Scientist: What Is the Greatest Challenge Facing Science? (SRI Magazine, 2015)
- CV: Dr. JoAnne McLaurin (Sept. 26, 2014)
- Dr. JoAnne McLaurin on understanding Alzheimer's disease (The Varsity, February 3, 2014)
- Infrastructure issues: Congestion and chaos on the brain's highways: This is neurodegeneration (SRI Magazine, 2013)
- Discovery District's first and breakthroughs: development of a vaccine for Alzheimer's disease.
- Alzheimer's research focuses on slowing disease (CBC, Sept. 21, 2006)
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