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SRI Profiles

William T. Tran


Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room TB 097
Toronto, ON
M4N 3M5

Phone: 416-480-6100, ext. 3746
Fax: 416-480-4672

Administrative Assistant: Stephanie Kulczyski
Phone: 416-480-6100, ext. 1026


  • B.Sc., 2003, anatomy and cell biology, McGill University, Canada
  • M.Sc., 2011, radiotherapy and oncology, Sheffield Hallam University, U.K.
  • PhD, 2018, Sheffield Hallam University, U.K.
  • Research fellow, 2018, radiation oncology, University of Toronto, Canada

Appointments and Affiliations:

  • Scientist, Evaluative Clinical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute
  • Staff radiation therapist, department of radiation oncology, Sunnybrook Health Sciences Centre
  • Assistant professor, department of radiation oncology, faculty of medicine, University of Toronto, Canada
  • Adjunct professor, department of physics, faculty of science, Ryerson University, Canada
  • Hon. senior research fellow (visiting assistant professor), department of radiotherapy and oncology, faculty of health and wellbeing, Sheffield Hallam University, U.K.

Research Foci:

  • Radiomics
  • Transcriptomics
  • Biomarkers for chemotherapy resistance in breast cancer

Research Summary:

The focus of Dr. Tran’s research is to identify predictive (i.e. pre-treatment) and early-response biomarkers for tumour response to chemotherapy and radiotherapy. Specifically, Dr. Tran is interested in exploring quantitative imaging biomarkers from computed tomography imaging, digital pathology, and optical imaging alongside specimen-based markers to design computer-aided theragnostic (CAT) systems. The primary endpoint of Dr. Tran’s research will be improved patient outcomes by using biomarker measurements for adaptive and response-guided cancer treatments.

Within this framework, Dr. Tran’s research is also focused on understanding treatment and survival outcomes associated with biological variances in early-stage invasive breast cancer. As part of a team of physician investigators and scientists, he is working alongside clinical experts to map the genetic and biological characteristics associated with chemotherapy resistance and radiation refractory breast cancer.

Selected Publications: 

See current publications list at PubMed.

  1. Tran William T., Gangeh Mehrdad, Sannachi Lakshmanan, Chin Lee, Watkins Elyse, Bruni Sylvio, Rastegar Rashin Fallah, Curpen Belinda, Trudeau Maureen, Gandhi Sonal, Yaffe Martin, Slodkowska Elzbieta, Childs Charmaine, Sadeghi-Naini Ali & Czarnota Gregory J. Predicting breast cancer response to neoadjuvant chemotherapy using pre-treatment diffuse optical spectroscopic-texture analysis. British J. Cancer. 2017.
  2. Tran WT, Childs C, Chin L, Slodkowska E, Sannachi L, Tadayyon H, Watkins E, Wong SL, Curpen B, El Kaffas A, Al-Mahrouki A, Sadeghi-Naini A, Czarnota GJ. Multiparametric monitoring of chemotherapy treatment response in locally advanced breast cancer using quantitative ultrasound and diffuse optical spectroscopy. Oncotarget. 2016 Apr 12;7(15):19762-80. doi: 10.18632/oncotarget.7844. PubMed PMID: 26942698; PubMed Central PMCID: PMC4991417.
  3. Tran WT, Iradji S, Sofroni E, Giles A, Eddy D, Czarnota GJ. Microbubble and ultrasound radioenhancement of bladder cancer. Br J Cancer. 2012 Jul 24;107(3):469-76. doi: 10.1038/bjc.2012.279. Epub 2012 Jul 12. PubMed PMID: 22790798; PubMed Central PMCID: PMC3405216.
  4. Merino T*, Tran WT*, Czarnota GJ. Re-irradiation for locally recurrent refractory breast cancer. Oncotarget. 2015 Oct 27;6(33):35051-62. doi: 10.18632/oncotarget.6036. PubMed PMID: 26459388; PubMed Central PMCID: PMC4741508. *Equal contribution.
  5. Sadeghi-Naini A, Sannachi L, Tadayyon H, Tran WT, Slodkowska E, Trudeau M, Gandhi S, Pritchard K, Kolios MC, Czarnota GJ. Chemotherapy-Response Monitoring of Breast Cancer Patients Using Quantitative Ultrasound-Based Intra-Tumour Heterogeneities. Sci Rep. 2017 Sep 4;7(1):10352. doi: 10.1038/s41598-017-09678-0. PubMed PMID: 28871171; PubMed Central PMCID: PMC5583340.

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