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Schulich Heart Research

SRI Programs

Dr. Jay Silverberg, MD, FRCPC, MACP

Affiliate scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room H1 49
Toronto, ON
M4N 3M5

Phone: 416-480-4761
Fax: 416-480-5258

Administrative Assistant: Valerie Wine
Phone: 416-480-4761
Fax: 416-480-5258


  • MD, 1972, University of Toronto, Canada
  • FRCPC, 1976, Royal College of Physicians and Surgeons of Canada
  • FACP, 1980, American College of Physicians, U.S.
  • MACP, 2012, American College of Physicians, U.S.

Appointments and Affiliations:

  • Affiliate scientist, Evaluative Clinical Sciences, Schulich Heart Research Program, Sunnybrook Research Institute
  • Staff endocrinologist, division of endocrinology and metabolism, Sunnybrook Health Sciences Centre
  • Professor, medicine, U of T
  • Member, history and archives committee, American Thyroid Association
  • Executive member, clinical and scientific section, Canadian Diabetes Association
  • Board member, Canadian Diabetes Association

Research Focus:

  • Type 2 diabetes and its complications
  • Cost-effectiveness issues of thyroid cancer

Research Summary:

Dr. Silverberg's research interests have included cognitive changes in thyroid disease, as well as clinical studies in diabetes prevention, diabetic nephropathy and the use of inhaled insulin.

His current research centres around studies in diabetes, with a focus on the role of inflammation in the development of vascular disease in patients with diabetes and its prevention with methotrexate. (He is the site principal investigator for the Cardiovascular Inflammation Reduction trial.)

Selected Publications:

See current publications list at PubMed.

  1. Dahele M, UngYC, Ehrlich L, Silverberg J, Balogh Wong CS. 18F-fluorodeoxyglucose positron emission tomography-computed tomography for suspected recurrent papillary thyroid cancer: early experience at Sunnybrook Health Sciences Centre. J Otolaryngol Head Neck Surg. 2008;37(5):712–7.
  2. Noble J, Baerlocher MO, Silverberg J. Management of type 2 diabetes mellitus: Role of thiazolidinediones. Can Fam Physician. 2005;51:683–7.
  3. Silverberg J, Taylor-Vassey A, Szalai JP, Tipping J: Lectures, interactive learning and knowledge retention in continuing medical education. Journal of Continuing Education in the Health Professions. 1995;15(4):231–4.
  4. Ozata M, Suzuki S, Takeda T, Malken DG, Miyamoto T, Liu R-T, Suzuki N, Silverberg JDH, Daneman D, DeGroot LJ. Functional analysis of a proline to serine mutation in codon 453 of the thyroid hormone receptor, beta-I bene. J Clin Endocrinol Metab. 1995;80(11):3239–3245.
  5. Morsi A, Jamal S, Silverberg, JDH. Pituitary apoplexy after leuprolide administration for carcinoma of the prostate. Clin Endocrinol. 1996;44:121–4.
  6. Bugaresti JM, Tator CH, Silverberg J, Szalai JP, Malkin DG, Malkin A, Tay SK. Changes in thyroid hormones, thyroid stimulating hormone and cortisol in acute spinal cord injury. Paraplegia. 1992;30(6):401–9.