Study title: Focused Ultrasound Conformal Array Helmet Fit Testing on Healthy Human Adults

Research Summary

The Weston Family Focused Ultrasound Initiative at Sunnybrook seeks to revolutionize the treatment of brain disorders such as Alzheimer's disease in a non-invasive way. Based on a model of personalization and portability, new patient-specific therapeutic headsets are being developed which are intended to make affordable, repeatable and reliable treatments a reality for thousands of people.

The purpose of this trial is to test the comfort and fit of these non-invasive devices, so that the manufacturing parameters can be finalized. Periodic participation may be requested up to a three-year period.

Participation in this research project will include:

• A screening/consenting in-person interview
• A 30-60-minute MRI scan to design a custom helmet to fit you
• An initial fit test up to 60 minutes to test if the helmet fits you
• Two follow-up visits for an extended fit test to evaluate wearing the helmet for a duration of 2-3.5 hours, with optional MRI imaging
• Two short follow-up phone interviews after each extended fit test
• Additional tests may be requested as the design improves

A small monetary gift and a souvenir will be offered to participants who complete the study.

Eligibility

Inclusion Criteria:

• Participants who are healthy adults between the ages of 18-70
• Participants who have short hair or no hair
• Participants who are able and willing to undergo MRI scans
• Participants who are able and willing to comply with study protocols and provide informed consent

Exclusion Criteria:

• Participants who have an acute or chronic disease
• Participants who are pregnant
• Participants who are unable to give informed consent and comply with study procedures