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Imaging-pathology correlation for clinical trials

As a research facility equipped for conducting early-phase clinical trials and both human and preclinical pilot studies, the biomarker imaging research lab has been part of many imaging clinical trials at Sunnybrook and beyond. These trials are aimed at improving current diagnostic methods by increasing accuracy and speed, measuring and predicting response to treatments, and validating new techniques related to imaging and biological markers for characterization of diseases. We are conducting a whole-mount tongue trial and a lumpectomy trial, and are continuing to analyze information from recently completed breast cancer trials.

Completed and in-progress imaging clinical trials include these ones:

  • Immunohistochemistry, computer tomography imaging and data analysis of carotid arteries for a study of the Canadian Atherosclerotic Imaging Network (principal investigator [PI]: Jean-Claude Tardif; in progress)
  • Whole-mount breast mastectomy trial (PI: Greg Czarnota) and lumpectomy trial (PI: Martin Yaffe; completed)
  • Photoacoustic imaging of prostate cancer in ex vivo post prostatectomy specimens (PIs: Masoom Haider and Brian Wilson; completed)
  • Correlation of [18F]fluoroazomycin-arabinoside (FAZA) PET hypoxia imaging to 3-D histology in oral tongue cancer (PI: Ian Poon; in progress)
  • Molecular and imaging biomarkers for precision therapy of breast cancer (PI: Martin Yaffe; in progress).