Imaging-genomics-transcriptomics profiling research

In a collaborative project with GE Global Research, we use breast cancer tissue specimens obtained from a cohort of women who are identified or presumed carriers of BRCA1 and 2 mutations, and their dynamic contrast-enhanced MRI image sets, to conduct genomics and transcriptomics analyses. The aim is to be able to associate genes or pathways related to features computed from images, and then identify their potential correlations to clinical outcomes. The goal is to find molecular changes that are linked to the imaging/radiological features, which may provide a better understanding of the phenotypic changes as a consequence of the underlying biological alterations, toward developing better tools for planning therapy and monitoring treatment response.