Speckle variance optical coherence tomography

With recent development in high-speed and multi-channel OCT systems, Dr. Yang’s group has introduced a computationally efficient method to image microvasculature based on temporal variations of speckle pattern in OCT images. The technique was applied to preclinical studies to provide detailed nonfluorophor- based imaging of microcirculation. Speckle variance OCT has also been used as a clinical imaging technique for skin vascular abnormalities and wide-field skin angiography for the study of complex vascular networks. Specifically, Dr. Yang’s group has investigated the microvasculature in human hereditary hemorrhagic telangiectasia. Read more about this research here.