MR-guided revascularization of occlusive arterial disease

Kevan Anderson, B.Sc.

My research focuses on the development of methods and technologies related to the MR-guided revascularization of occlusive arterial disease.

The presence of occlusive arterial disease is the leading reason for selection of bypass surgery over less invasive interventions. Despite the benefits of percutaneous treatment, clinicians are often unable to go over total occlusions with catheter-based devices because current imaging tools cannot show the lesion composition and the position of the device relative to the vessel wall. MRI’s soft tissue contrast can be used to overcome these limitations and real-time acquisition techniques can be used to guide a percutaneous revascularization.

My research involves:

1. Methods for improved catheter tracking that exploit the spatial phase distribution of the MR signal around small micro-coils
2. The development of a forward-looking intravascular coil for high temporal and spatial resolution imaging of occlusive disease
3. Methods for visualizing MR-safe guidewires

References

1. Anderson K J T, Dick A J, Wright G A.  Catheter Tracking using Phase Information.  Proceedings of the 12th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Kyoto, Japan, 2004.  Abstract 2690.  Pg. 498. (e-Poster)
2. Kevan J. T. Anderson, Graham A. Wright.  Catheter Tracking using Phase Information.  Patent filed in the US Patent Office.  April 28, 2004. Application number: 11/115, 416.
3. Bradley H. Strauss, Amit Segev, Graham A. Wright, Beiping Qiang, Nigel Munce, Kevan J. T. Anderson, General Leung, Alexander J. Dick, Renu Virmani, Jagdish Butany.  Microvessels in Chronic Total Occlusions: Pathway for Successful Guidewire Crossing?  J Interv Cardiol. 2005 Oct;18(6).
4. Kevan J. T. Anderson, General Leung, Nigel Munce, Beiping Qiang, Erin MacMillan, John Graham, Alan R. Moody, Alexander J. Dick, Bradley H. Strauss, Graham A. Wright. Contrast-Enhanced MRI of Occlusive Arterial Disease.  9th Annual Meeting of the Society for Cardiovascular Magnetic Resonance, Miami, USA, 2006. (Poster)
5. K . J. T. Anderson, L. Biswas, G. A. Wright.  Intravascular Phased-Array Coil for Image-Guided Treatment of Vascular Occlusions.  Abstract accepted to the ISMRM Workshop on Real-Time MRI: Dynamic Interactive Imaging and its Applications, Santa Monica, USA, 2006. (Oral Presentation)
6. Anderson KJT, Graham J J, Leung G, Munce N, Dick AJ, Wright GA.  Phased-Array Coil for Image-Guided Treatment of Occlusive Arterial Disease.  14th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Seattle, USA, 2006.  3356. 
7. Anderson KJT, Biswas L, Chung D, Huang J, Wright Graham A. Correcting Static Interventional Roadmaps for Subject Displacement in Real-Time Using One-Dimensional Projections. 15th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Berlin, Germany, 2007.