Connectivity

The completion of cognition and tasks requires the orchestration of spatiotemporal processes distributed in the brain. In connectivity analysis, we interrogate how activities at different brain areas are synchronized in time (functional connectivity). We also attempt to reveal how information is transmitted and integrated across brain areas underlying a task or a condition (effective connectivity). We use MRI, magnetoencephalography and electroencephalogrqphy to study the structural, functional and effective connectivity at the system level.

Selected publications

Wu PY, Chu YH, Lin JL, Kuo WJ, Lin FH. Feature-dependent intrinsic functional connectivity across cortical depths in the human auditory cortex. Sci Rep. 2018 Sep 5;8(1):13287. doi: 10.1038/s41598-018-31292-x.

Jääskeläinen IP, Pajula J, Tohka J, Lee HJ, Kuo WJ, Lin FH. Brain hemodynamic activity during viewing and re-viewing of comedy movies explained by experienced humor. Sci Rep. 2016 Jun 21;6:27741. doi:10.1038/srep27741

Lin FH, Ahveninen J, Raij T, Witzel T, Chu YH, Jääskeläinen IP, Tsai KW, Kuo WJ, Belliveau JW. Increasing fMRI sampling rate improves Granger causality estimates. PLoS One. 2014 Jun 26;9(6):e100319. doi: 10.1371/journal.pone.0100319.

Chu YH, Lin FH, Chou YJ, Tsai KW, Kuo WJ, Jääskeläinen IP. Effective cerebral connectivity during silent speech reading revealed by functional magnetic resonance imaging. PLoS One. 2013 Nov 21;8(11):e80265. doi:10.1371/journal.pone.0080265

Lin FH, Agnew JA, Belliveau JW, Zeffiro TA. Functional and effective connectivity of visuomotor control systems demonstrated using generalized partial least squares and structural equation modeling. Hum Brain Mapp. 2009 Jul;30(7):2232–51.

Lin FH, Hara K, Solo V, Vangel M, Belliveau J, Stufflebeam S, Hämäläinen M. Dynamic Granger-Geweke causality modeling with application to interictal spike propagation. Hum Brain Mapp. 2009 Jun;30(6):1877–96.

Lin FH, Witzel T, Hämäläinen MS, Dale AM, Belliveau JW, Stufflebeam SM. Spectral spatiotemporal imaging of cortical oscillations and interactions in the human brain. Neuroimage. 2004 Oct;23(2):582–95.